DHTKD1 - Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial - human protein (Function)
 
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DHTKD1 »  Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial   [ EC 1.2.4.2 ]
 
Protein also known as:  Dehydrogenase E1 and transketolase domain-containing protein 1.
Gene name:  DHTKD1
Entry whose protein(s) existence is based on evidence at protein level
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1 20 1
GENE REF ISO

Function

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Overview 
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Oxoglutarate dehydrogenase (succinyl-transferring) activitydefinition[GO:0004591]  
  • IEAEC 2 GO
Thiamine pyrophosphate bindingdefinition[GO:0030976] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • IMPUniProtKB
Glycolysisdefinition[GO:0006096]  
  • IEAUniProtKB KW
Tricarboxylic acid cycledefinition[GO:0006099] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.2.4.2: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).  
  • CuratedUniProtKB
It requires the following cofactor
Thiamine pyrophosphate (By similarity).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 55526
PRO: PR:Q96HY7