ABCC11 - ATP-binding cassette sub-family C member 11 - human protein (Function)
 
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Protein
Gene
References

 
ABCC11 »  ATP-binding cassette sub-family C member 11
 
Protein also known as:  Multidrug resistance-associated protein 8.
Gene name:  ABCC11
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 52 2
GENE REF ISO

Function

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Overview 
Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.  
3
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.208.13  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
ABC transporters  hsa02010+85320  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCC11
GenomeRNAi: 85320
PRO: PR:Q96J66