CDK5RAP3 - CDK5 regulatory subunit-associated protein 3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
CDK5RAP3 »  CDK5 regulatory subunit-associated protein 3
 
Protein also known as:  LXXLL/leucine-zipper-containing ARF-binding protein.
Gene name:  CDK5RAP3
Family name: CDK5RAP3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 45 4
GENE REF ISO

Function

 show evidences
Overview 
Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed12054757, PubMed12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed17785205, PubMed20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed15790566, PubMed19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed21283629).  
11
  • UniProtKB
(Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.  
1
  • UniProtKB
GO molecular function 
Cyclin bindingdefinition[GO:0030332]  
1
  • UniProtKB
MDM2/MDM4 family protein bindingdefinition[GO:0097371]  
1
  • UniProtKB
Mitogen-activated protein kinase bindingdefinition[GO:0051019]  
1
  • UniProtKB
NF-kappaB bindingdefinition[GO:0051059]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
2
  • UniProtKB
Ubiquitin-like protein ligase bindingdefinition[GO:0044389]  
1
  • MGI
GO biological process 
Apoptotic nuclear changesdefinition[GO:0030262]  
1
  • UniProtKB
Brain developmentdefinition[GO:0007420]  
1
  • UniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • UniProtKB
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
1
  • UniProtKB
Mitotic G2 DNA damage checkpointdefinition[GO:0007095]  
1
  • UniProtKB
Mitotic G2/M transition checkpointdefinition[GO:0044818]  
1
  • UniProtKB
Negative regulation of cellular protein catabolic processdefinition[GO:1903363]  
1
  • UniProtKB
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • UniProtKB
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
2
  • UniProtKB
Negative regulation of protein kinase activity by regulation of protein phosphorylationdefinition[GO:0044387]  
1
  • UniProtKB
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • UniProtKB
Negative regulation of protein serine/threonine kinase activitydefinition[GO:0071901]  
1
  • UniProtKB
Positive regulation of protein localization to nucleusdefinition[GO:1900182]  
1
  • UniProtKB
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • UniProtKB
Not  Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:2000060]  
1
  • UniProtKB
Positive regulation of signal transduction by p53 class mediatordefinition[GO:1901798]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Protein ufmylationdefinition[GO:0071569]  
1
  • MGI
Regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0000079]  
2
  • RefGenome
  • Ortholog Curator
Regulation of neuron differentiationdefinition[GO:0045664]  
1
  • UniProtKB
Regulation of phosphatase activitydefinition[GO:0010921]  
1
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDK5RAP3
GenomeRNAi: 80279
PRO: PR:Q96JB5