AKR1E2 - 1,5-anhydro-D-fructose reductase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
AKR1E2 »  1,5-anhydro-D-fructose reductase   [ EC 1.1.1.263 ]  (AF reductase)
 
Protein also known as:  Aldo-keto reductase family 1 member C-like protein 2.
Gene name:  AKR1E2
Family name: Aldo/keto reductase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 5
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro).  
  • CuratedUniProtKB
GO molecular function 
1,5-anhydro-D-fructose reductase activitydefinition[GO:0050571]  
  • IEAEC 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.263: 1,5-anhydro-D-glucitol + NADP(+) 1,5-anhydro-D-fructose + NADPH.  
  • CuratedUniProtKB
Pathways 
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 6.1 uM for 9,10-phenanthrenequinone with NADPH as cofactor
Vmax 0.42 nmol/min/mg enzyme towards 9,10-phenanthrenequinone with NADPH as cofactor

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 83592
PRO: PR:Q96JD6