USP47 - Ubiquitin carboxyl-terminal hydrolase 47 - human protein (Function)
 
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USP47 »  Ubiquitin carboxyl-terminal hydrolase 47   [ EC 3.4.19.12 ]
 
Protein also known as:  Ubiquitin-specific-processing protease 47.
Gene name:  USP47
Family name: Peptidase C19
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Ubiquitin thiolesterase activitydefinition[GO:0004221] silver  
  • IEAInterPro 2 GO
Ubiquitin-specific protease activitydefinition[GO:0004843]  
1
  • IDAUniProtKB
WD40-repeat domain bindingdefinition[GO:0071987]  
1
  • IPIUniProtKB
GO biological process 
Base-excision repairdefinition[GO:0006284]  
1
  • IMPUniProtKB
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IMPUniProtKB
Cellular response to UVdefinition[GO:0034644]  
1
  • ISSUniProtKB
Monoubiquitinated protein deubiquitinationdefinition[GO:0035520]  
1
  • IDAUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • IMPUniProtKB
Negative regulation of G2/M transition of mitotic cell cycledefinition[GO:0010972]  
1
  • IMPUniProtKB
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:1902230] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IMPUniProtKB
Positive regulation of cell growthdefinition[GO:0030307]  
1
  • IMPUniProtKB
Response to drugdefinition[GO:0042493]  
1
  • IMPUniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
1
  • CuratedUniProtKB
 
More information is available from:
Caution 
Was initially thought to catalytically inactive (PubMed14715245). However, it was later shown that it is active (PubMed21362556).  
2
  • CuratedUniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: USP47
GenomeRNAi: 55031
PRO: PR:Q96K76