PBK - Lymphokine-activated killer T-cell-originated protein kinase - human protein (Function)
 
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PBK »  Lymphokine-activated killer T-cell-originated protein kinase   [ EC 2.7.12.2 ]
 
Protein also known as:  Spermatogenesis-related protein kinase (SPK).
Gene name:  PBK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB
GO biological process 
Cellular response to UVdefinition[GO:0034644] silver  
1
  • Ortholog Compara
Mitotic nuclear divisiondefinition[GO:0007067]  
1
  • UniProtKB
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
1
  • Ortholog Compara
Negative regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032435] silver  
1
  • Ortholog Compara
Negative regulation of protein phosphorylationdefinition[GO:0001933] silver  
1
  • Ortholog Compara
Negative regulation of stress-activated MAPK cascadedefinition[GO:0032873] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • InterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.2: ATP + a protein ADP + a phosphoprotein.  
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  • UniProtKB
It is regulated in the following manner
Activated by phosphorylation.  
1
  • UniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PBK_(gene)
GenomeRNAi: 55872
PRO: PR:Q96KB5
Chemistry
GuidetoPHARMACOLOGY: 2140