PPP1R13B - Apoptosis-stimulating of p53 protein 1 - human protein (Function)
 
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PPP1R13B »  Apoptosis-stimulating of p53 protein 1
 
Protein also known as:  Protein phosphatase 1 regulatory subunit 13B.
Gene name:  PPP1R13B
Family name: ASPP
Entry whose protein(s) existence is based on evidence at protein level
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1 40 1
GENE REF ISO

Function

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Overview 
Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
Transcription factor bindingdefinition[GO:0008134] silver  
  • IEAInterPro 2 GO
GO biological process 
Intrinsic apoptotic signaling pathway by p53 class mediatordefinition[GO:0072332]  
1
  • IDAUniProtKB
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • TASUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPP1R13B
GenomeRNAi: 23368
PRO: PR:Q96KQ4