CALR3 - Calreticulin-3 - human protein (Function)
 
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Gene
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CALR3 »  Calreticulin-3
 
Protein also known as:  Calreticulin-2.
Gene name:  CALR3
Family name: Calreticulin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.  
2
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Carbohydrate bindingdefinition[GO:0030246]  
1
  • UniProtKB KW
Protein binding involved in protein foldingdefinition[GO:0044183] silver  
1
  • Ortholog Compara
Unfolded protein bindingdefinition[GO:0051082] silver  
1
  • InterPro 2 GO
GO biological process 
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Protein foldingdefinition[GO:0006457] silver  
1
  • InterPro 2 GO
Spermatogenesisdefinition[GO:0007283]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 125972
PRO: PR:Q96L12