MARK4 - MAP/microtubule affinity-regulating kinase 4 - human protein (Function)
 
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MARK4 »  MAP/microtubule affinity-regulating kinase 4   [ EC 2.7.11.1 ]
 
Protein also known as:  MAP/microtubule affinity-regulating kinase-like 1.
Gene name:  MARK4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • NASUniProtKB
Gamma-tubulin bindingdefinition[GO:0043015]  
1
  • IDAUniProtKB
Microtubule bindingdefinition[GO:0008017]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
Tau-protein kinase activitydefinition[GO:0050321]  
1
  • IDAUniProtKB
Ubiquitin bindingdefinition[GO:0043130]  
1
  • NASUniProtKB
GO biological process 
Microtubule bundle formationdefinition[GO:0001578]  
1
  • IEPUniProtKB
Microtubule cytoskeleton organizationdefinition[GO:0000226]  
1
  • IMPUniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • IDAUniProtKB
Positive regulation of programmed cell deathdefinition[GO:0043068]  
1
  • NASUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation on Thr-214.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MARK4
GenomeRNAi: 57787
PRO: PR:Q96L34
Chemistry
GuidetoPHARMACOLOGY: 2100