SENP8 - Sentrin-specific protease 8 - human protein (Function)
 
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SENP8 »  Sentrin-specific protease 8   [ EC 3.4.22.68 ]
 
Protein also known as:  Sentrin/SUMO-specific protease SENP8.
Gene name:  SENP8
Family name: Peptidase C48
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.  
5
  • CuratedUniProtKB
GO molecular function 
Cysteine-type peptidase activitydefinition[GO:0008234]  
  • IEAUniProtKB KW
GO biological process 
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.68: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.  
  • CuratedUniProtKB
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM for Ub-AMC exceeds 5uM.
KM 51 nM for Nedd8-AMC

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SENP8
GenomeRNAi: 123228
PRO: PR:Q96LD8
Chemistry
GuidetoPHARMACOLOGY: 2417