SAMD8 - Sphingomyelin synthase-related protein 1 - human protein (Function)
 
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Protein
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References

 
SAMD8 »  Sphingomyelin synthase-related protein 1   [ EC 2.7.8.- ]  (SMSr)
 
Protein also known as:  Sterile alpha motif domain-containing protein 8 (SAM domain-containing protein 8).
Gene name:  SAMD8
Family name: Sphingomyelin synthase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 16 2
GENE REF ISO

Function

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Overview 
Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.  
1
  • CuratedUniProtKB
GO molecular function 
Transferase activitydefinition[GO:0016740]  
  • IEAUniProtKB KW
GO biological process 
Ceramide biosynthetic processdefinition[GO:0046513]  
1
  • IDAUniProtKB
Regulation of ceramide biosynthetic processdefinition[GO:2000303]  
1
  • IDAUniProtKB
Sphingomyelin biosynthetic processdefinition[GO:0006686]  
1
  • NASUniProtKB
 

Keywords

Biological process 
Lipid metabolism  definition   [KW-0443]
Sphingolipid metabolism  definition   [KW-0746]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 142891
PRO: PR:Q96LT4