AK7 - Adenylate kinase 7 - human protein (Function)
 
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AK7 »  Adenylate kinase 7   [ EC 2.7.4.6EC 2.7.4.3 ]  (AK 7)
 
Protein also known as:  ATP-AMP transphosphorylase 7.
Gene name:  AK7
Family names: In the central section Adenylate kinase
In the C-terminal section Dpy-30
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.  
3
  • UniProtKB
GO molecular function 
Adenylate kinase activitydefinition[GO:0004017]  
1
  • UniProtKB
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Cytidylate kinase activitydefinition[GO:0004127]  
1
  • UniProtKB
Nucleoside diphosphate kinase activitydefinition[GO:0004550]  
1
  • UniProtKB
GO biological process 
Axoneme assemblydefinition[GO:0035082] silver  
1
  • Ortholog Compara
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Epithelial cilium movementdefinition[GO:0003351] silver  
1
  • Ortholog Compara
Inflammatory response to antigenic stimulusdefinition[GO:0002437] silver  
1
  • Ortholog Compara
Nucleoside diphosphate phosphorylationdefinition[GO:0006165]  
1
  • UniProtKB
Nucleoside triphosphate biosynthetic processdefinition[GO:0009142]  
1
  • UniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.4.3: ATP + AMP 2 ADP.  
1
  • UniProtKB
EC 2.7.4.6: ATP + nucleoside diphosphate ADP + nucleoside triphosphate.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+122481  
Purine metabolism  hsa00230+122481  
 

Biophysicochemical properties

Kinetic parameters
KM 1.2 uM for CMP
KM 1.0 uM for AMP
KM 28 uM for dAMP
Vmax 1130 pmol/min/ug enzyme with AMP as substrate
Vmax 860 pmol/min/ug enzyme with dAMP as substrate
Vmax 150 pmol/min/ug enzyme with CMP as substrate

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 122481
PRO: PR:Q96M32