AK7 - Adenylate kinase 7 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
AK7 »  Adenylate kinase 7   [ EC 2.7.4.3EC 2.7.4.6 ]  (AK 7)
 
Protein also known as:  ATP-AMP transphosphorylase 7.
Gene name:  AK7
Family names: In the central section Adenylate kinase
In the C-terminal section Dpy-30
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 19 1
GENE REF ISO

Function

 show evidences
Overview 
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.  
2
  • CuratedUniProtKB
GO molecular function 
Adenylate kinase activitydefinition[GO:0004017]  
1
  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cytidylate kinase activitydefinition[GO:0004127]  
1
  • IDAUniProtKB
Nucleoside diphosphate kinase activitydefinition[GO:0004550]  
1
  • IDAUniProtKB
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cell projection organizationdefinition[GO:0030030]  
  • IEAUniProtKB KW
Epithelial cilium movementdefinition[GO:0003351] silver  
  • IEAOrtholog Compara
Inflammatory response to antigenic stimulusdefinition[GO:0002437] silver  
  • IEAOrtholog Compara
Nucleoside diphosphate phosphorylationdefinition[GO:0006165]  
1
  • IDAUniProtKB
Nucleoside triphosphate biosynthetic processdefinition[GO:0009142]  
1
  • IDAUniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.4.3: ATP + AMP 2 ADP.  
2
  • CuratedUniProtKB
EC 2.7.4.6: ATP + nucleoside diphosphate ADP + nucleoside triphosphate.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+122481  
Purine metabolism  hsa00230+122481  
 

Biophysicochemical properties

Kinetic parameters
KM 1.2 uM for CMP
KM 1.0 uM for AMP
KM 28 uM for dAMP
Vmax 1130 pmol/min/ug enzyme with AMP as substrate
Vmax 860 pmol/min/ug enzyme with dAMP as substrate
Vmax 150 pmol/min/ug enzyme with CMP as substrate

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 122481
PRO: PR:Q96M32