AK8 - Adenylate kinase 8 - human protein (Function)
 
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AK8 »  Adenylate kinase 8   [ EC 2.7.4.3EC 2.7.4.6 ]  (AK 8)
 
Protein also known as:  ATP-AMP transphosphorylase 8.
Gene name:  AK8
Family name: Adenylate kinase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.  
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  • CuratedUniProtKB
GO molecular function 
Adenylate kinase activitydefinition[GO:0004017]  
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  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cytidylate kinase activitydefinition[GO:0004127]  
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  • IDAUniProtKB
Nucleoside diphosphate kinase activitydefinition[GO:0004550]  
1
  • IDAUniProtKB
GO biological process 
Nucleoside diphosphate phosphorylationdefinition[GO:0006165]  
1
  • IDAUniProtKB
Nucleoside triphosphate biosynthetic processdefinition[GO:0009142]  
1
  • IDAUniProtKB
Ventricular system developmentdefinition[GO:0021591] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.4.3: ATP + AMP 2 ADP.  
2
  • CuratedUniProtKB
EC 2.7.4.6: ATP + nucleoside diphosphate ADP + nucleoside triphosphate.  
2
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 4.1 uM for AMP
KM 630 uM for dAMP
KM 1.4 uM for CMP
Vmax 1360 pmol/min/ug enzyme with dAMP as substrate
Vmax 190 pmol/min/ug enzyme with CMP as substrate
Vmax 2400 pmol/min/ug enzyme with AMP as substrate

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 158067
PRO: PR:Q96MA6