AGBL1 - Cytosolic carboxypeptidase 4 - human protein (Function)
 
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AGBL1 »  Cytosolic carboxypeptidase 4   [ EC 3.4.17.- ]
 
Protein also known as:  ATP/GTP-binding protein-like 1.
Gene name:  AGBL1
Family name: Peptidase M14
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Metallocarboxypeptidase activitydefinition[GO:0004181]  
  • ISSOrtholog Curator
Tubulin bindingdefinition[GO:0015631]  
  • ISSOrtholog Curator
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
C-terminal protein deglutamylationdefinition[GO:0035609]  
  • ISSOrtholog Curator
Protein side chain deglutamylationdefinition[GO:0035610]  
  • ISSOrtholog Curator
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Carboxypeptidase  definition   [KW-0121]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 123624
PRO: PR:Q96MI9