HS6ST2 - Heparan-sulfate 6-O-sulfotransferase 2 - human protein (Function)
 
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Protein
Gene
References

 
HS6ST2 »  Heparan-sulfate 6-O-sulfotransferase 2   [ EC 2.8.2.- ]  (HS6ST-2)
 
Gene name:  HS6ST2
Family name: Sulfotransferase 6
Entry whose protein(s) existence is based on evidence at protein level
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1 17 4
GENE REF ISO

Function

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Overview 
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.  
1
  • UniProtKB
GO molecular function 
Heparan sulfate 6-O-sulfotransferase activitydefinition[GO:0017095] silver  
1
  • Ortholog Compara
GO biological process 
Heparan sulfate proteoglycan biosynthetic process, enzymatic modificationdefinition[GO:0015015] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.8.2.-: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Glycosaminoglycan biosynthesis - heparan sulfate  hsa00534+90161  
According to Reactome, this protein belongs to the following pathway:
HS-GAG biosynthesis  REACT_121248  
 

Keywords

Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 90161
PRO: PR:Q96MM7