PRICKLE1 - Prickle-like protein 1 - human protein (Function)
 
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Protein
Gene
References

 
PRICKLE1 »  Prickle-like protein 1
 
Protein also known as:  REST/NRSF-interacting LIM domain protein 1.
Gene name:  PRICKLE1
Entry whose protein(s) existence is based on evidence at protein level
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1 36 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IDABHF-UCL
Negative regulation of cardiac muscle cell myoblast differentiationdefinition[GO:2000691]  
1
  • IDAUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDABHF-UCL
Neural tube closuredefinition[GO:0001843]  
1
  • IMPUniProtKB
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
1
  • IDABHF-UCL
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • IDABHF-UCL
Protein import into nucleusdefinition[GO:0006606]  
3
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Wnt signaling pathway  hsa04310+144165  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 144165
PRO: PR:Q96MT3