CEP63 - Centrosomal protein of 63 kDa - human protein (Function)
 
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CEP63 »  Centrosomal protein of 63 kDa  (Cep63)
 
Gene name:  CEP63
Family name: CEP63
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed21983783, PubMed26297806). Also recruits CDK1 to centrosomes (PubMed21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed21406398).  
4
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • UniProtKB KW
Centriole replicationdefinition[GO:0007099]  
2
  • RefGenome
  • Ortholog Curator
De novo centriole assemblydefinition[GO:0098535]  
1
  • RefGenome
DNA damage checkpointdefinition[GO:0000077]  
1
  • Ortholog Curator
Mitotic nuclear divisiondefinition[GO:0007067]  
1
  • UniProtKB KW
Signal transduction in response to DNA damagedefinition[GO:0042770]  
1
  • Ortholog Curator
Spindle assemblydefinition[GO:0051225]  
1
  • Ortholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathways:
Anchoring of the basal body to the plasma membrane  R-HSA-5620912  
Loss of Nlp from mitotic centrosomes  R-HSA-380259  
Recruitment of mitotic centrosome proteins and complexes  R-HSA-380270  
Regulation of PLK1 Activity at G2/M Transition  R-HSA-2565942  
Note 
CEP63 and CCDC67/DEUP1 paralogs are both involved in centriole amplification: while CEP63 mediates mother-centriole-dependent centriole duplication, CCDC67/DEUP1 mediates de novo centriole amplification in multiciliated cells.  
1
  • UniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
DNA damage  definition   [KW-0227]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CEP63
GenomeRNAi: 80254
PRO: PR:Q96MT8