CEP63 - Centrosomal protein of 63 kDa - human protein (Function)
 
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CEP63 »  Centrosomal protein of 63 kDa  (Cep63)
 
Gene name:  CEP63
Family name: CEP63
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication, through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Centriole replicationdefinition[GO:0007099]  
  • ISSOrtholog Curator
DNA damage checkpointdefinition[GO:0000077]  
  • ISSOrtholog Curator
Mitotic nuclear divisiondefinition[GO:0007067]  
  • IEAUniProtKB KW
Signal transduction in response to DNA damagedefinition[GO:0042770]  
  • ISSOrtholog Curator
Spindle assemblydefinition[GO:0051225]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathways:
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
Note 
CEP63 and CCDC67/DEUP1 paralogs are both involved in centriole amplification: while CEP63 mediates mother-centriole-dependent centriole duplication, CCDC67/DEUP1 mediates de novo centriole amplification in multiciliated cells.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
DNA damage  definition   [KW-0227]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CEP63
GenomeRNAi: 80254
PRO: PR:Q96MT8