SLC46A1 - Proton-coupled folate transporter - human protein (Function)
 
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Protein
Gene
References

 
SLC46A1 »  Proton-coupled folate transporter
 
Protein also known as:  Solute carrier family 46 member 1.
Gene name:  SLC46A1
Family name: Major facilitator » SLC46A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 57 2
GENE REF ISO

Function

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Overview 
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.50.1  
GO molecular function 
Folic acid bindingdefinition[GO:0005542]  
  • IEAUniProtKB KW
Folic acid transporter activitydefinition[GO:0008517]  
2
  • IDAUniProtKB
Heme transporter activitydefinition[GO:0015232] silver  
  • IEAOrtholog Compara
Methotrexate transporter activitydefinition[GO:0015350] silver  
  • IEAOrtholog Compara
GO biological process 
Folic acid transportdefinition[GO:0015884]  
2
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Mineral absorption  hsa04978+113235  
Vitamin digestion and absorption  hsa04977+113235  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
 

Biophysicochemical properties

Kinetic parameters
KM 56.2 uM for folic acid (at pH 7.5)
KM 1.3 uM for folic acid (at pH 5.5)
KM 2.7 uM for folic acid (at pH 6.5)
KM 1.5 uM for folic acid (at pH 6.0)
KM 6.0 uM for folic acid (at pH 7.0)
Dependence
pH Optimum pH is 4.0-5.5. Activity decreases above pH 5.5 and reaches negligible levels at neutral pH and above.

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SLC46A1
GenomeRNAi: 113235
PRO: PR:Q96NT5
Chemistry
GuidetoPHARMACOLOGY: 1213