AMDHD1 - Probable imidazolonepropionase - human protein (Function)
 
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Protein
Gene
References

 
AMDHD1 »  Probable imidazolonepropionase
 
Gene name:  AMDHD1
Family name: HutI
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
Imidazolonepropionase activitydefinition[GO:0050480]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Histidine catabolic process to glutamate and formamidedefinition[GO:0019556]  
  • IEAUniPathway
Histidine catabolic process to glutamate and formatedefinition[GO:0019557]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.2.7: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H(2)O N-formimidoyl-L-glutamate + H(+).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc or iron ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Histidine metabolism  hsa00340+144193  
Metabolic pathways  hsa01100+144193  
According to Reactome, this protein belongs to the following pathway:
Histidine catabolism  REACT_1249  
 

Keywords

Biological process 
Histidine metabolism  definition   [KW-0369]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 144193
PRO: PR:Q96NU7