DACH2 - Dachshund homolog 2 - human protein (Function)
 
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Protein
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References

 
DACH2 »  Dachshund homolog 2  (Dach2)
 
Gene name:  DACH2
Family name: DACH/dachshund
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
GO biological process 
Development of primary female sexual characteristicsdefinition[GO:0046545] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DACH2
GenomeRNAi: 117154
PRO: PR:Q96NX9