GPR124 - G-protein coupled receptor 124 - human protein (Function)
 
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GPR124 »  G-protein coupled receptor 124
 
Protein also known as:  Tumor endothelial marker 5.
Gene name:  GPR124
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity).  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
GO biological process 
Central nervous system developmentdefinition[GO:0007417]  
  • ISSOrtholog Curator
Endothelial cell migrationdefinition[GO:0043542]  
  • ISSOrtholog Curator
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASGDB
Negative regulation of vascular endothelial growth factor signaling pathwaydefinition[GO:1900747] silver  
  • IEAOrtholog Compara
Neuropeptide signaling pathwaydefinition[GO:0007218] silver  
  • IEAInterPro 2 GO
Positive regulation of endothelial cell migrationdefinition[GO:0010595] silver  
  • IEAOrtholog Compara
Regulation of angiogenesisdefinition[GO:0045765]  
  • ISSOrtholog Curator
Regulation of chemotaxisdefinition[GO:0050920]  
  • ISSOrtholog Curator
Regulation of establishment of blood-brain barrierdefinition[GO:0090210] silver  
  • IEAOrtholog Compara
Sprouting angiogenesisdefinition[GO:0002040]  
  • ISSOrtholog Curator
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GPR124
GenomeRNAi: 25960
PRO: PR:Q96PE1