NOX5 - NADPH oxidase 5 - human protein (Function)
 
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NOX5 »  NADPH oxidase 5   [ EC 1.6.3.- ]
 
Gene name:  NOX5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 44 6
GENE REF ISO

Function

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Overview 
Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis.  
3
  • CuratedUniProtKB
Isoforms  v2 and v5   Are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.  
3
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the phagocyte (gp91(phox)) nadph oxidase family  5.B.1.1.5  
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Flavin adenine dinucleotide bindingdefinition[GO:0050660]  
1
  • NASUniProtKB
Heme bindingdefinition[GO:0020037]  
1
  • NASUniProtKB
Hydrogen ion channel activitydefinition[GO:0015252]  
1
  • IDAUniProtKB
NADP bindingdefinition[GO:0050661]  
1
  • NASUniProtKB
Isoform  v2   Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Superoxide-generating NADPH oxidase activitydefinition[GO:0016175]  
1
  • IDAUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • IDAUniProtKB
  • IEAUniProtKB KW
Apoptotic processdefinition[GO:0006915]  
1
  • NASUniProtKB
Cation transportdefinition[GO:0006812]  
1
  • IDAGOC
Cell proliferationdefinition[GO:0008283]  
1
  • NASUniProtKB
Cytokine secretiondefinition[GO:0050663]  
1
  • NASUniProtKB
Cytokinesisdefinition[GO:0000910]  
1
  • NASUniProtKB
Isoform  v2   Endothelial cell proliferationdefinition[GO:0001935]  
1
  • IDAUniProtKB
Ion transmembrane transportdefinition[GO:0034220]  
1
  • IDAGOC
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Isoforms  v2 and v5   Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • IDAUniProtKB
Proton transportdefinition[GO:0015992]  
1
  • IDAGOC
Regulation of fusion of sperm to egg plasma membranedefinition[GO:0043012]  
1
  • NASUniProtKB
Regulation of proton transportdefinition[GO:0010155]  
1
  • NASUniProtKB
Superoxide anion generationdefinition[GO:0042554]  
1
  • IDAUniProtKB
Transmembrane transportdefinition[GO:0055085]  
1
  • IDAGOC
Enzymatic activity 
It requires the following cofactors
FAD.  
1
  • CuratedUniProtKB
Magnesium.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Activated by calcium which induces conformational changes and interaction between the N-terminal regulatory region and the C-terminal catalytic region. Inhibited by diphenylene iodonium.  
1
  • CuratedUniProtKB
 
More information is available from:
  • PeroxiBase: 6024 [ HsNOx05 ]
 

Biophysicochemical properties

Kinetic parameters
KM 1.06 uM for calcium

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Electron transport  definition   [KW-0249]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NOX5
GenomeRNAi: 79400
PRO: PR:Q96PH1