ADCY10 - Adenylate cyclase type 10 - human protein (Function)
 
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Protein
Gene
References

 
ADCY10 »  Adenylate cyclase type 10   [ EC 4.6.1.1 ]
 
Protein also known as:  Testicular soluble adenylyl cyclase.
Gene name:  ADCY10
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed15659711, PubMed24616449, PubMed25040695, PubMed24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed15659711, PubMed17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed17591988).  
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  • UniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
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  • UniProtKB
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
ATPase bindingdefinition[GO:0051117] silver  
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  • Ortholog Compara
Bicarbonate bindingdefinition[GO:0071890]  
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  • UniProtKB
Magnesium ion bindingdefinition[GO:0000287] silver  
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  • InterPro 2 GO
Manganese ion bindingdefinition[GO:0030145] silver  
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  • Ortholog Compara
GO biological process 
cAMP biosynthetic processdefinition[GO:0006171]  
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  • UniProtKB
Cellular response to inorganic substancedefinition[GO:0071241]  
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  • UniProtKB
Epithelial cilium movementdefinition[GO:0003351]  
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  • UniProtKB
Intracellular signal transductiondefinition[GO:0035556] silver  
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  • InterPro 2 GO
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
1
  • Ortholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
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  • InterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
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  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 2 magnesium ions per subunit (PubMed25040695). Is also active with manganese (in vitro) (PubMed12609998, PubMed15659711, PubMed24616449).  
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  • UniProtKB
It is regulated in the following manner
Activated by manganese or magnesium ions (PubMed12609998, PubMed24616449). In the presence of magnesium ions, the enzyme is activated by bicarbonate (PubMed12609998, PubMed15659711, PubMed24567411). In the presence of manganese ions, the enzyme is inhibited by bicarbonate (PubMed15659711). In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium (PubMed15659711). Calcium mildly increases the enzyme activity, also in the presence of magnesium ions (PubMed15659711, PubMed25040695).  
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  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Purine metabolism  hsa00230+55811  
According to Reactome, this protein belongs to the following pathway:
Hedgehog 'off' state  R-HSA-5610787  
 

Biophysicochemical properties

Kinetic parameters
KM 2.41 mM for Mg(2+)
KM 0.8 mM for ATP-Mn(2+)

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY10
GenomeRNAi: 55811
PRO: PR:Q96PN6