ADCY10 - Adenylate cyclase type 10 - human protein (Function)
 
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ADCY10 »  Adenylate cyclase type 10   [ EC 4.6.1.1 ]
 
Protein also known as:  Testicular soluble adenylyl cyclase.
Gene name:  ADCY10
Entry whose protein(s) existence is based on evidence at protein level
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1 42 4
GENE REF ISO

Function

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Overview 
Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.  
2
  • CuratedUniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
1
  • NASUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase bindingdefinition[GO:0051117] silver  
  • IEAOrtholog Compara
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Manganese ion bindingdefinition[GO:0030145] silver  
  • IEAOrtholog Compara
GO biological process 
cAMP biosynthetic processdefinition[GO:0006171]  
1
  • NASUniProtKB
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium ions per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by manganese or magnesium ions. In the presence of magnesium ions, the enzyme is activated by bicarbonate while in the presence of manganese ions, the enzyme is inhibited by bicarbonate. In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Purine metabolism  hsa00230+55811  
 

Biophysicochemical properties

Kinetic parameters
KM 2.41 mM for Mg(2+)
KM 0.8 mM for ATP-Mn(2+)

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY10
GenomeRNAi: 55811
PRO: PR:Q96PN6