KCNC2 - Potassium voltage-gated channel subfamily C member 2 - human protein (Function)
 
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KCNC2 »  Potassium voltage-gated channel subfamily C member 2
 
Protein also known as:  Voltage-gated potassium channel Kv3.2.
Gene name:  KCNC2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity).  
6
  • UniProtKB
GO molecular function 
Delayed rectifier potassium channel activitydefinition[GO:0005251]  
2
  • Ortholog Curator
  • RefGenome
Ion channel bindingdefinition[GO:0044325] silver  
1
  • Ortholog Compara
Voltage-gated potassium channel activitydefinition[GO:0005249]  
1
  • Ortholog Curator
GO biological process 
Action potentialdefinition[GO:0001508] silver  
1
  • Ortholog Compara
Cellular response to ammonium iondefinition[GO:0071242] silver  
1
  • Ortholog Compara
Cellular response to nitric oxidedefinition[GO:0071732]  
1
  • Ortholog Curator
Cellular response to toxic substancedefinition[GO:0097237] silver  
1
  • Ortholog Compara
Globus pallidus developmentdefinition[GO:0021759] silver  
1
  • Ortholog Compara
Nitric oxide-cGMP-mediated signaling pathwaydefinition[GO:0038060]  
1
  • Ortholog Curator
Positive regulation of potassium ion transmembrane transportdefinition[GO:1901381] silver  
1
  • Ortholog Compara
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • Ortholog Curator
  • RefGenome
Protein heterooligomerizationdefinition[GO:0051291]  
1
  • Ortholog Curator
Protein homooligomerizationdefinition[GO:0051260]  
1
  • Ortholog Curator
Response to aminedefinition[GO:0014075] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to light intensitydefinition[GO:0009642] silver  
1
  • Ortholog Compara
Response to magnesium iondefinition[GO:0032026] silver  
1
  • Ortholog Compara
Response to nerve growth factordefinition[GO:1990089] silver  
1
  • Ortholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
1
  • Ortholog Compara
Enzymatic activity 
It is regulated in the following manner
Inhibited by Stichodactyla helianthus peptide ShK (PubMed15709110). Inhibited by millimolar levels of tetraethylammonium (TEA). Contrary to other channels, inhibited only by millimolar levels of 4-aminopyridine (4-AP) (By similarity).  
4
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  R-HSA-381676  
Voltage gated Potassium channels  R-HSA-1296072  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNC2
GenomeRNAi: 3747
PRO: PR:Q96PR1
Chemistry
GuidetoPHARMACOLOGY: 549