SYNGAP1 - Ras/Rap GTPase-activating protein SynGAP - human protein (Function)
 
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SYNGAP1 »  Ras/Rap GTPase-activating protein SynGAP
 
Protein also known as:  Synaptic Ras GTPase-activating protein 1 (Synaptic Ras-GAP 1).
Gene name:  SYNGAP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
2 33 4
GENE REF ISO

Function

 show evidences
Overview 
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).  
1
  • UniProtKB
GO molecular function 
GTPase activator activitydefinition[GO:0005096]  
1
  • RefGenome
SH3 domain bindingdefinition[GO:0017124]  
1
  • UniProtKB KW
GO biological process 
Negative regulation of Ras protein signal transductiondefinition[GO:0046580]  
2
  • Ortholog Curator
  • RefGenome
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • RefGenome
Regulation of synaptic plasticitydefinition[GO:0048167]  
1
  • Ortholog Curator
Signal transductiondefinition[GO:0007165] silver  
1
  • InterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Regulation of RAS by GAPs  R-HSA-5658442  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SYNGAP1
GenomeRNAi: 8831
PRO: PR:Q96PV0