SYNGAP1 - Ras/Rap GTPase-activating protein SynGAP - human protein (Function)
 
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SYNGAP1 »  Ras/Rap GTPase-activating protein SynGAP
 
Protein also known as:  Synaptic Ras GTPase-activating protein 1 (Synaptic Ras-GAP 1).
Gene name:  SYNGAP1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Rab GTPase activator activitydefinition[GO:0005097] silver  
  • IEAOrtholog Compara
Ras GTPase activator activitydefinition[GO:0005099] silver  
  • IBARefGenome
SH3 domain bindingdefinition[GO:0017124]  
  • IEAUniProtKB KW
GO biological process 
Dendrite developmentdefinition[GO:0016358] silver  
  • IEAOrtholog Compara
Negative regulation of axonogenesisdefinition[GO:0050771] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of Ras protein signal transductiondefinition[GO:0046580]  
  • IBARefGenome
  • ISSOrtholog Curator
Pattern specification processdefinition[GO:0007389] silver  
  • IEAOrtholog Compara
Positive regulation of Ras GTPase activitydefinition[GO:0032320] silver  
  • IBARefGenome
Ras protein signal transductiondefinition[GO:0007265] silver  
  • IEAOrtholog Compara
Receptor clusteringdefinition[GO:0043113] silver  
  • IEAOrtholog Compara
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169] silver  
  • IEAOrtholog Compara
Regulation of MAPK cascadedefinition[GO:0043408] silver  
  • IEAOrtholog Compara
Regulation of synapse structure and activitydefinition[GO:0050803] silver  
  • IEAOrtholog Compara
Regulation of synaptic plasticitydefinition[GO:0048167]  
  • ISSOrtholog Curator
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SYNGAP1
GenomeRNAi: 8831
PRO: PR:Q96PV0