NEK1 - Serine/threonine-protein kinase Nek1 - human protein (Function)
 
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NEK1 »  Serine/threonine-protein kinase Nek1   [ EC 2.7.11.1 ]
 
Protein also known as:  Never in mitosis A-related kinase 1 (NimA-related protein kinase 1).
Gene name:  NEK1
Entry whose protein(s) existence is based on evidence at protein level
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1 40 6
GENE REF ISO

Function

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Overview 
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • IDAMGI
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • IEAUniProtKB KW
GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974] silver  
  • IEAOrtholog Compara
Cilium assemblydefinition[GO:0042384]  
1
  • IMPUniProtKB
Mitotic nuclear divisiondefinition[GO:0007067]  
  • IEAUniProtKB KW
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • IEAUniProtKB KW
Response to ionizing radiationdefinition[GO:0010212] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Cilium biogenesis/degradation  definition   [KW-0970]
Mitosis  definition   [KW-0498]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: NEK1
GenomeRNAi: 4750
PRO: PR:Q96PY6
Chemistry
GuidetoPHARMACOLOGY: 2114