SMG1 - Serine/threonine-protein kinase SMG1 - human protein (Function)
 
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SMG1 »  Serine/threonine-protein kinase SMG1   [ EC 2.7.11.1 ]  (SMG-1)
 
Protein also known as:  Lambda/iota protein kinase C-interacting protein (Lambda-interacting protein).
Gene name:  SMG1
Family name: PI3/PI4-kinase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
1
  • TASUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
4
  • IDAUniProtKB
GO biological process 
DNA repairdefinition[GO:0006281]  
  • IEAUniProtKB KW
mRNA export from nucleusdefinition[GO:0006406]  
1
  • TASUniProtKB
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decaydefinition[GO:0000184]  
3
  • TASUniProtKB
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
3
  • IDAUniProtKB
Phosphatidylinositol phosphorylationdefinition[GO:0046854]  
1
  • IDAUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
2
  • IDAUniProtKB
Response to stressdefinition[GO:0006950]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactor
Manganese.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by caffeine, LY294002 and wortmannin.  
3
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
mRNA surveillance pathway  hsa03015+23049  
According to Reactome, this protein belongs to the following pathway:
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)  REACT_75822  
Note 
This gene is located in a region of chromosome 16 that contains 2 segmental duplications. Other genes that are highly related to this exist, but they probably represent pseudogenes.  
  • CuratedUniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Nonsense-mediated mRNA decay  definition   [KW-0866]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SMG1_(gene)
GenomeRNAi: 23049
PRO: PR:Q96Q15