ALS2 - Alsin - human protein (Function)
 
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ALS2 »  Alsin
 
Protein also known as:  Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein.
Gene name:  ALS2
Entry whose protein(s) existence is based on evidence at protein level
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1 62 3
GENE REF ISO

Function

 show evidences
Overview 
May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
Contributes to guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Protein serine/threonine kinase activator activitydefinition[GO:0043539]  
1
  • IDAUniProtKB
Rab GTPase bindingdefinition[GO:0017137]  
2
  • NASUniProtKB
Rab guanyl-nucleotide exchange factor activitydefinition[GO:0017112]  
1
  • IDAUniProtKB
Rac guanyl-nucleotide exchange factor activitydefinition[GO:0030676]  
1
  • IDAUniProtKB
Ran guanyl-nucleotide exchange factor activitydefinition[GO:0005087]  
1
  • NASUniProtKB
GO biological process 
Behavioral fear responsedefinition[GO:0001662] silver  
  • IEAOrtholog Compara
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Endosomal transportdefinition[GO:0016197] silver  
  • IEAOrtholog Compara
Endosome organizationdefinition[GO:0007032]  
2
  • IGIMGI
  • NASUniProtKB
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Neuromuscular junction developmentdefinition[GO:0007528] silver  
  • IEAOrtholog Compara
Neuron projection morphogenesisdefinition[GO:0048812]  
1
  • IDAUniProtKB
Positive regulation of protein kinase activitydefinition[GO:0045860]  
1
  • IDAUniProtKB
Positive regulation of protein serine/threonine kinase activitydefinition[GO:0071902]  
1
  • IDAGOC
Positive regulation of Rac GTPase activitydefinition[GO:0032855]  
1
  • IDAUniProtKB
Positive regulation of Rac protein signal transductiondefinition[GO:0035022]  
1
  • ICUniProtKB
Protein localizationdefinition[GO:0008104] silver  
  • IEAOrtholog Compara
Receptor recyclingdefinition[GO:0001881] silver  
  • IEAOrtholog Compara
Regulation of endosome sizedefinition[GO:0051036]  
1
  • IEPUniProtKB
Regulation of Rac GTPase activitydefinition[GO:0032314]  
1
  • IDAGOC
Regulation of Ran GTPase activitydefinition[GO:0032316]  
1
  • NASGOC
Response to oxidative stressdefinition[GO:0006979] silver  
  • IEAOrtholog Compara
Synaptic transmission, glutamatergicdefinition[GO:0035249] silver  
  • IEAOrtholog Compara
Vesicle organizationdefinition[GO:0016050] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Amyotrophic lateral sclerosis (ALS)  hsa05014+57679  
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALS2
GenomeRNAi: 57679
PRO: PR:Q96Q42