DERL3 - Derlin-3 - human protein (Function)
 
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Protein
Gene
References

 
DERL3 »  Derlin-3
 
Protein also known as:  Degradation in endoplasmic reticulum protein 3 (DERtrin-3).
Gene name:  DERL3
Family name: Derlin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
1
  • IDAUniProtKB
ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:0030433]  
2
  • IMPUniProtKB
Protein N-linked glycosylation via asparaginedefinition[GO:0018279]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+91319  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Derlin-3
GenomeRNAi: 91319
PRO: PR:Q96Q80