VPS35 - Vacuolar protein sorting-associated protein 35 - human protein (Function)
 
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Protein
Gene
References

 
VPS35 »  Vacuolar protein sorting-associated protein 35
 
Protein also known as:  Vesicle protein sorting 35.
Gene name:  VPS35
Family name: VPS35
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed15078903, PubMed15247922, PubMed20164305). Required for endosomal localization of FAM21C (PubMed22070227). Mediates the association of the CSC with the WASH complex via FAM21 (PubMed22070227, PubMed24980502, PubMed24819384). Required for the endosomal localization of TBC1D5 (PubMed20923837).  
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  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
  • AgBase
Protein transporter activitydefinition[GO:0008565]  
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  • RefGenome
GO biological process 
Intracellular protein transportdefinition[GO:0006886]  
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  • RefGenome
Negative regulation of late endosome to lysosome transportdefinition[GO:1902823]  
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  • UniProtKB
Retrograde transport, endosome to Golgidefinition[GO:0042147]  
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  • UniProtKB
Retrograde transport, endosome to plasma membranedefinition[GO:1990126]  
2
  • UniProtKB
Transcytosisdefinition[GO:0045056]  
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  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
WNT ligand biogenesis and trafficking  REACT_163710  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: VPS35
GenomeRNAi: 55737
PRO: PR:Q96QK1