PASK - PAS domain-containing serine/threonine-protein kinase - human protein (Function)
 
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PASK »  PAS domain-containing serine/threonine-protein kinase   [ EC 2.7.11.1 ]  (PASKIN)
 
Gene name:  PASK
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Phosphatidylinositol bindingdefinition[GO:0035091]  
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  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • IDAUniProtKB
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
GO biological process 
Negative regulation of glycogen biosynthetic processdefinition[GO:0045719]  
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  • IDAUniProtKB
Positive regulation of translationdefinition[GO:0045727]  
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  • TASUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
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  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
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  • IDAUniProtKB
Regulation of energy homeostasisdefinition[GO:2000505]  
  • ISSOrtholog Curator
Regulation of glucagon secretiondefinition[GO:0070092]  
  • ISSOrtholog Curator
Regulation of respiratory gaseous exchangedefinition[GO:0043576]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1161 and Thr-1165 (PubMed11459942). The activating role of autophosphorylation at Thr-1161 is unclear: according to a report, autophosphorylation at Thr-1161 does not play a major role in activation (PubMed20943661). Autophosphorylation is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri-phosphate).  
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  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PASK
GenomeRNAi: 23178
PRO: PR:Q96RG2
Chemistry
GuidetoPHARMACOLOGY: 2139