F2RL3 - Proteinase-activated receptor 4 - human protein (Function)
 
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F2RL3 »  Proteinase-activated receptor 4  (PAR-4)
 
Protein also known as:  Coagulation factor II receptor-like 3.
Gene name:  F2RL3
Entry whose protein(s) existence is based on evidence at protein level
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1 64 1
GENE REF ISO

Function

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Overview 
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.  
1
  • CuratedUniProtKB
GO molecular function 
Thrombin receptor activitydefinition[GO:0015057] silver  
  • IEAInterPro 2 GO
GO biological process 
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • TASPINC
Platelet dense granule organizationdefinition[GO:0060155]  
1
  • ICBHF-UCL
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281]  
1
  • IDABHF-UCL
Response to woundingdefinition[GO:0009611]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
2
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+9002  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: F2RL3
GenomeRNAi: 9002
PRO: PR:Q96RI0
Chemistry
GuidetoPHARMACOLOGY: 350