NR1H4 - Bile acid receptor - human protein (Function)
 
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NR1H4 »  Bile acid receptor
 
Protein also known as:  Nuclear receptor subfamily 1 group H member 4.
Gene name:  NR1H4
Family name: Nuclear hormone receptor » NR1
Entry whose protein(s) existence is based on evidence at protein level
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1 169 5
GENE REF ISO

Function

 show evidences
Overview 
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.  
8
  • CuratedUniProtKB
GO molecular function 
Bile acid bindingdefinition[GO:0032052]  
2
  • TASBHF-UCL
Bile acid receptor activitydefinition[GO:0038181]  
1
  • IDAUniProtKB
Chenodeoxycholic acid bindingdefinition[GO:1902122]  
1
  • IDAUniProtKB
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • ISSBHF-UCL
Ligand-dependent nuclear receptor bindingdefinition[GO:0016922]  
1
  • TASBHF-UCL
Peptide bindingdefinition[GO:0042277] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
Retinoid X receptor bindingdefinition[GO:0046965] silver  
  • IEAOrtholog Compara
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • IDABHF-UCL
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
1
  • IDABHF-UCL
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001190]  
1
  • IDABHF-UCL
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • TASPINC
Steroid hormone receptor activitydefinition[GO:0003707] silver  
  • IEAOrtholog Compara
Thyroid hormone receptor activitydefinition[GO:0004887] silver  
  • IEAInterPro 2 GO
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
Transcription corepressor activitydefinition[GO:0003714]  
1
  • TASPINC
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Bile acid metabolic processdefinition[GO:0008206] silver  
  • IEAOrtholog Compara
Cellular response to acid chemicaldefinition[GO:0071229]  
1
  • IDABHF-UCL
Cellular response to organonitrogen compounddefinition[GO:0071417]  
1
  • ISSBHF-UCL
Digestive tract developmentdefinition[GO:0048565] silver  
  • IEAOrtholog Compara
Intracellular bile acid receptor signaling pathwaydefinition[GO:0038185]  
1
  • IDAUniProtKB
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
  • ISSOrtholog Curator
Negative regulation of bile acid biosynthetic processdefinition[GO:0070858]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • ISSBHF-UCL
Nitrogen catabolite activation of transcription from RNA polymerase II promoterdefinition[GO:0001080]  
1
  • ICBHF-UCL
Positive regulation of ammonia assimilation cycledefinition[GO:2001250] silver  
  • IEAOrtholog Compara
Positive regulation of glutamate metabolic processdefinition[GO:2000213]  
1
  • ISSBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPBHF-UCL
Regulation of bile acid biosynthetic processdefinition[GO:0070857]  
1
  • TASBHF-UCL
Regulation of carbohydrate metabolic processdefinition[GO:0006109] silver  
  • IEAOrtholog Compara
Regulation of cholesterol metabolic processdefinition[GO:0090181]  
1
  • TASBHF-UCL
Regulation of urea metabolic processdefinition[GO:0034255]  
1
  • ISSBHF-UCL
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bile secretion  hsa04976+9971  
According to Reactome, this protein belongs to the following pathway:
Nuclear Receptor transcription pathway  REACT_15525  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Farnesoid_X_receptor
GenomeRNAi: 9971
PRO: PR:Q96RI1
Chemistry
GuidetoPHARMACOLOGY: 603