PEO1 - Twinkle protein, mitochondrial - human protein (Function)
 
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Protein
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PEO1 »  Twinkle protein, mitochondrial   [ EC 3.6.4.12 ]
 
Protein also known as:  T7 gp4-like protein with intramitochondrial nucleoid localization.
Gene name:  PEO1
Entry whose protein(s) existence is based on evidence at protein level
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1 66 3
GENE REF ISO

Function

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Overview 
Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.  
2
  • CuratedUniProtKB
GO molecular function 
5'-3' DNA helicase activitydefinition[GO:0043139]  
2
  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protease bindingdefinition[GO:0002020]  
1
  • IPIUniProtKB
Single-stranded DNA bindingdefinition[GO:0003697]  
1
  • IDAUniProtKB
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
DNA unwinding involved in DNA replicationdefinition[GO:0006268] silver  
  • IEAOrtholog Compara
Mitochondrial DNA replicationdefinition[GO:0006264]  
2
  • IMPUniProtKB
Protein hexamerizationdefinition[GO:0034214]  
1
  • IDAUniProtKB
Protein homooligomerizationdefinition[GO:0051260]  
1
  • IDAUniProtKB
Transcription from mitochondrial promoterdefinition[GO:0006390]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
 

Keywords

Biological process 
DNA replication  definition   [KW-0235]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PEO1
GenomeRNAi: 56652
PRO: PR:Q96RR1