SLC22A12 - Solute carrier family 22 member 12 - human protein (Function)
 
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Protein
Gene
References

 
SLC22A12 »  Solute carrier family 22 member 12
 
Protein also known as:  Organic anion transporter 4-like protein.
Gene name:  SLC22A12
Entry whose protein(s) existence is based on evidence at protein level
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1 65 4
GENE REF ISO

Function

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Overview 
Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.19.11  
GO molecular function 
PDZ domain bindingdefinition[GO:0030165]  
1
  • IPIUniProtKB
Urate transmembrane transporter activitydefinition[GO:0015143]  
1
  • IDAUniProtKB
GO biological process 
Cellular homeostasisdefinition[GO:0019725]  
1
  • NASUniProtKB
Organic acid transportdefinition[GO:0015849]  
1
  • IDAGOC
Response to drugdefinition[GO:0042493]  
1
  • IDAUniProtKB
Urate metabolic processdefinition[GO:0046415]  
1
  • IMPBHF-UCL
Urate transportdefinition[GO:0015747]  
2
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC22A12
GenomeRNAi: 116085
PRO: PR:Q96S37