TESK2 - Dual specificity testis-specific protein kinase 2 - human protein (Function)
 
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TESK2 »  Dual specificity testis-specific protein kinase 2   [ EC 2.7.12.1 ]
 
Protein also known as:  Testicular protein kinase 2.
Gene name:  TESK2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
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  • IntAct
Protein kinase activitydefinition[GO:0004672]  
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  • PINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • Ortholog Curator
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
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  • EC 2 GO
Protein tyrosine kinase activitydefinition[GO:0004713]  
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  • UniProtKB KW
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
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  • Ortholog Curator
Focal adhesion assemblydefinition[GO:0048041]  
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  • Ortholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
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  • UniProtKB KW
Protein phosphorylationdefinition[GO:0006468]  
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  • Ortholog Curator
Spermatogenesisdefinition[GO:0007283]  
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  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.1: ATP + a protein ADP + a phosphoprotein.  
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  • UniProtKB
It requires the following cofactors
 Mg(2+)  
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  • UniProtKB
 Mn(2+)  
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  • UniProtKB
It is regulated in the following manner
Activated by autophosphorylation on Ser-219.  
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  • UniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TESK2
GenomeRNAi: 10420
PRO: PR:Q96S53
Chemistry
GuidetoPHARMACOLOGY: 2240