RANBP9 - Ran-binding protein 9 - human protein (Function)
 
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RANBP9 »  Ran-binding protein 9  (RanBP9)
 
Protein also known as:  Ran-binding protein M (RanBPM).
Gene name:  RANBP9
Family name: RANBP9/10
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 59 2
GENE REF ISO

Function

 show evidences
Overview 
May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity).  
7
  • CuratedUniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Ran GTPase bindingdefinition[GO:0008536]  
1
  • TASPINC
GO biological process 
Microtubule nucleationdefinition[GO:0007020]  
1
  • NASUniProtKB
Protein complex assemblydefinition[GO:0006461]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
L1CAM interactions  REACT_22205  
Caution 
According to some authors (PubMed9817760) RANBP9 would be located in centrosomes and involved in microtubule assembly, but other authors infirmed these results in (PubMed11470507).  
2
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RANBP9
GenomeRNAi: 10048
PRO: PR:Q96S59