CCT8L2 » Putative T-complex protein 1 subunit theta-like 2

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Gene name: CCT8L2

Family name: TCP-1 chaperonin

The existence of this protein is dubious . Could be the product of a pseudogene.

Protein

Recommended name: Putative T-complex protein 1 subunit theta-like 2

Gene

Recommended name: CCT8L2
Alternative name: CESK1

Family

Family: TCP-1 chaperonin

History

neXtProt: Integrated 2010-03-08; Last updated 2013-02-17
UniProtKB: Integrated 2008-09-02; Updated 2012-11-28; Entry version 74; Last sequence update 2010-11-30; Sequence version 2; Complete UniProtKB history

The existence of this protein is dubious

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1 9 1

GENE REF ISO

Function

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Overview

Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis (By similarity).

CuratedUniProtKB

GO molecular function

Anion channel activitydefinition[GO:0005253]

Catalysis of the energy-independent passage of anions across a lipid bilayer down a concentration gradient.

Evidence 1: Traceable Author Statement PINC

Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2.

Riazi M.A., Brinkman-Mills P., Johnson A., Naylor S.L., Minoshima S., Shimizu N., Baldini A., McDermid H.E.

Genomics 62, 90-94 (1999) [Full text:10.1006/geno.1999.5975] [PubMed:10585773]

Duplication of a segment of the long arm of human chromosome 3 (3q26.3-q27) results in a syndrome characterized by multiple congenital abnormalities and neurological anomalies in some patients. We have identified a novel gene (KCNMB3) that maps to this region. KCNMB3 has significant sequence similarity to the regulatory subunit of the large-conductance calcium-activated potassium channel. Due to the significance of potassium channels in neuronal functions, the overexpression of this gene may play a role in the abnormal neurological functions seen in some of these patients. A related sequence corresponding to the second and third exons of this gene resides in the pericentromeric region of 22q11, where a number of other unprocessed pseudogenes are known to map.

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TASPINC

ATP bindingdefinition[GO:0005524]

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEAUniProtKB KW

Calcium-activated potassium channel activitydefinition[GO:0015269]

Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.

Evidence 1: Traceable Author Statement PINC

Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2.

Riazi M.A., Brinkman-Mills P., Johnson A., Naylor S.L., Minoshima S., Shimizu N., Baldini A., McDermid H.E.

Genomics 62, 90-94 (1999) [Full text:10.1006/geno.1999.5975] [PubMed:10585773]

Duplication of a segment of the long arm of human chromosome 3 (3q26.3-q27) results in a syndrome characterized by multiple congenital abnormalities and neurological anomalies in some patients. We have identified a novel gene (KCNMB3) that maps to this region. KCNMB3 has significant sequence similarity to the regulatory subunit of the large-conductance calcium-activated potassium channel. Due to the significance of potassium channels in neuronal functions, the overexpression of this gene may play a role in the abnormal neurological functions seen in some of these patients. A related sequence corresponding to the second and third exons of this gene resides in the pericentromeric region of 22q11, where a number of other unprocessed pseudogenes are known to map.

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TASPINC

GO biological process

Cellular protein metabolic processdefinition[GO:0044267] ‹silver

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.

IEAInterPro 2 GO

Transportdefinition[GO:0006810]

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.

Evidence 1: Traceable Author Statement PINC

Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2.

Riazi M.A., Brinkman-Mills P., Johnson A., Naylor S.L., Minoshima S., Shimizu N., Baldini A., McDermid H.E.

Genomics 62, 90-94 (1999) [Full text:10.1006/geno.1999.5975] [PubMed:10585773]

Duplication of a segment of the long arm of human chromosome 3 (3q26.3-q27) results in a syndrome characterized by multiple congenital abnormalities and neurological anomalies in some patients. We have identified a novel gene (KCNMB3) that maps to this region. KCNMB3 has significant sequence similarity to the regulatory subunit of the large-conductance calcium-activated potassium channel. Due to the significance of potassium channels in neuronal functions, the overexpression of this gene may play a role in the abnormal neurological functions seen in some of these patients. A related sequence corresponding to the second and third exons of this gene resides in the pericentromeric region of 22q11, where a number of other unprocessed pseudogenes are known to map.

ref

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TASPINC

Keywords

Molecular function

Chaperone definition [KW-0143]

Protein which is transiently involved in the noncovalent folding, assembly and/or disassembly of other polypeptides or RNA molecules, including any transport and oligomerisation processes they may undergo, and the refolding and reassembly of protein and RNA molecules denatured by stress. Though involved in these processes, chaperones are not an integral part of these functioning molecules. Also used for metallochaperones, which function to provide a metal directly to target proteins while protecting this metal from scavengers.

Technical term

Reference proteome definition [KW-1185]

A reference proteome is a set of protein sequences derived from a complete proteome which constitutes a defined standard for a particular user community. Reference proteomes are manually defined according to a number of criteria. They cover the proteomes of well- studied model organisms and other proteomes of interest for biomedical and biotechnological research. Reference proteomes have been selected to provide broad coverage of the tree of life, and constitute a representative cross-section of the taxonomic diversity to be found within UniProtKB.

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Function

Keywords

neXtProt