CCT8L2 - T-complex protein 1 subunit theta-like 2 - human protein (Function)
 
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CCT8L2 »  T-complex protein 1 subunit theta-like 2
 
Gene name:  CCT8L2
Family name: TCP-1 chaperonin
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.  
1
  • UniProtKB
GO molecular function 
Anion channel activitydefinition[GO:0005253]  
1
  • PINC
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Calcium-activated potassium channel activitydefinition[GO:0015269]  
1
  • PINC
GO biological process 
Anion transmembrane transportdefinition[GO:0098656]  
1
  • GOC
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • GOC
Transportdefinition[GO:0006810]  
1
  • PINC
Note 
Presence of two highly similar CCT8L genes (CCT8L1P and CCT8L2) in the genomes of human and chimp and of a single copy in other mammal genomes, including rhesus monkey, suggests that the duplication of this gene occurred in the ape lineage (Hominoidea) after its divergence from the old-world monkeys (Cercopithecidae).  
2
  • UniProtKB
Expression of CCT8L2 is confirmed by many ESTs mostly identified from the testis.  
2
  • UniProtKB
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 150160