ATOH8 - Protein atonal homolog 8 - human protein (Function)
 
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Protein
Gene
References

 
ATOH8 »  Protein atonal homolog 8
 
Protein also known as:  Class A basic helix-loop-helix protein 21 (bHLHa21).
Gene name:  ATOH8
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 13 2
GENE REF ISO

Function

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Overview 
Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (PubMed24236640). Regulates endothelial cell proliferation, migration and tube-like structures formation (PubMed24463812). Modulates endothelial cell differentiation through NOS3 (PubMed24463812). May be implicated in specification and differentiation of neuronal cell lineages in the brain (By similarity). May participate in kidney development and may be involved in podocyte differentiation (By similarity). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (By similarity). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (By similarity). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (PubMed24236640). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (By similarity).  
4
  • UniProtKB
GO molecular function 
Activating transcription factor bindingdefinition[GO:0033613] silver  
1
  • Ortholog Compara
E-box bindingdefinition[GO:0070888]  
1
  • UniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • UniProtKB
GO biological process 
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Formation of primary germ layerdefinition[GO:0001704]  
1
  • Ortholog Curator
Myoblast proliferationdefinition[GO:0051450]  
1
  • Ortholog Curator
Negative regulation of endothelial cell proliferationdefinition[GO:0001937]  
1
  • UniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • Ortholog Curator
Nervous system developmentdefinition[GO:0007399]  
1
  • UniProtKB KW
Positive regulation of endothelial cell differentiationdefinition[GO:0045603]  
2
  • UniProtKB
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
SMAD protein signal transductiondefinition[GO:0060395]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Tube formationdefinition[GO:0035148]  
1
  • UniProtKB
Caution 
Contains a degenerate basic motif not likely to bind DNA.  
2
  • UniProtKB
  • PROSITE-ProRule
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84913
PRO: PR:Q96SQ7