SIN3A - Paired amphipathic helix protein Sin3a - human protein (Function)
 
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SIN3A »  Paired amphipathic helix protein Sin3a
 
Protein also known as:  Histone deacetylase complex subunit Sin3a.
Gene name:  SIN3A
Entry whose protein(s) existence is based on evidence at protein level
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1 91 1
GENE REF ISO

Function

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Overview 
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
14
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein deacetylase activitydefinition[GO:0033558]  
1
  • IMPBHF-UCL
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • IPIBHF-UCL
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103] silver  
  • IEAOrtholog Compara
RNA polymerase II transcription corepressor activitydefinition[GO:0001106] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
Transcription corepressor activitydefinition[GO:0003714]  
1
  • RCAUniProtKB
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976]  
  • ISSOrtholog Curator
GO biological process 
Activation of innate immune responsedefinition[GO:0002218]  
1
  • IMPBHF-UCL
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cellular protein localizationdefinition[GO:0034613] silver  
  • IEAOrtholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
DNA replicationdefinition[GO:0006260] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of circadian rhythmdefinition[GO:0042754]  
  • ISSOrtholog Curator
Negative regulation of histone H3-K27 acetylationdefinition[GO:1901675]  
1
  • IMPBHF-UCL
Negative regulation of protein localization to nucleusdefinition[GO:1900181]  
1
  • IMPBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IMPBHF-UCL
Negative regulation of transcription regulatory region DNA bindingdefinition[GO:2000678]  
1
  • IMPBHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Positive regulation of chromatin silencingdefinition[GO:0031937]  
1
  • IMPBHF-UCL
Positive regulation of defense response to virus by hostdefinition[GO:0002230]  
1
  • IMPBHF-UCL
Positive regulation of G2/M transition of mitotic cell cycledefinition[GO:0010971] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPBHF-UCL
Protein deacetylationdefinition[GO:0006476]  
1
  • IMPBHF-UCL
Regulation of transcription from RNA polymerase II promoter in response to oxidative stressdefinition[GO:0043619] silver  
  • IEAOrtholog Compara
Response to methylglyoxaldefinition[GO:0051595] silver  
  • IEAOrtholog Compara
Response to organonitrogen compounddefinition[GO:0010243] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Huntington's disease  hsa05016+25942  
According to Reactome, this protein belongs to the following pathways:
Gene Expression  REACT_71  
Hemostasis  REACT_604  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SIN3A
GenomeRNAi: 25942
PRO: PR:Q96ST3