SIN3A - Paired amphipathic helix protein Sin3a - human protein (Function)
 
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SIN3A »  Paired amphipathic helix protein Sin3a
 
Protein also known as:  Histone deacetylase complex subunit Sin3a.
Gene name:  SIN3A
Entry whose protein(s) existence is based on evidence at protein level
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1 93 1
GENE REF ISO

Function

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Overview 
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
14
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein deacetylase activitydefinition[GO:0033558]  
1
  • IMPBHF-UCL
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • IPIBHF-UCL
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103] silver  
  • IEAOrtholog Compara
RNA polymerase II transcription corepressor activitydefinition[GO:0001106] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
Transcription corepressor activitydefinition[GO:0003714]  
1
  • RCAUniProtKB
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976]  
  • ISSOrtholog Curator
GO biological process 
Activation of innate immune responsedefinition[GO:0002218]  
1
  • IMPBHF-UCL
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cellular protein localizationdefinition[GO:0034613] silver  
  • IEAOrtholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
DNA replicationdefinition[GO:0006260] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of circadian rhythmdefinition[GO:0042754]  
  • ISSOrtholog Curator
Negative regulation of histone H3-K27 acetylationdefinition[GO:1901675]  
1
  • IMPBHF-UCL
Negative regulation of protein localization to nucleusdefinition[GO:1900181]  
1
  • IMPBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IMPBHF-UCL
Negative regulation of transcription regulatory region DNA bindingdefinition[GO:2000678]  
1
  • IMPBHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Positive regulation of chromatin silencingdefinition[GO:0031937]  
1
  • IMPBHF-UCL
Positive regulation of defense response to virus by hostdefinition[GO:0002230]  
1
  • IMPBHF-UCL
Positive regulation of G2/M transition of mitotic cell cycledefinition[GO:0010971] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPBHF-UCL
Protein deacetylationdefinition[GO:0006476]  
1
  • IMPBHF-UCL
Regulation of transcription from RNA polymerase II promoter in response to oxidative stressdefinition[GO:0043619] silver  
  • IEAOrtholog Compara
Response to methylglyoxaldefinition[GO:0051595] silver  
  • IEAOrtholog Compara
Response to organonitrogen compounddefinition[GO:0010243] silver  
  • IEAOrtholog Compara
Rhythmic processdefinition[GO:0048511]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Huntington's disease  hsa05016+25942  
According to Reactome, this protein belongs to the following pathways:
Factors involved in megakaryocyte development and platelet production  REACT_24970  
NoRC negatively regulates rRNA expression  REACT_200856  
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)  REACT_19241  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SIN3A
GenomeRNAi: 25942
PRO: PR:Q96ST3