YME1L1 - ATP-dependent zinc metalloprotease YME1L1 - human protein (Function)
 
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YME1L1 »  ATP-dependent zinc metalloprotease YME1L1   [ EC 3.4.24.- ]
 
Protein also known as:  Presenilin-associated metalloprotease (PAMP).
Gene name:  YME1L1
Family names: In the N-terminal section AAA ATPase
In the C-terminal section Peptidase M41
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 24 3
GENE REF ISO

Function

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Overview 
Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Nucleoside-triphosphatase activitydefinition[GO:0017111] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • IMPUniProtKB
Misfolded or incompletely synthesized protein catabolic processdefinition[GO:0006515]  
1
  • IMPUniProtKB
Mitochondrion organizationdefinition[GO:0007005]  
1
  • IMPUniProtKB
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (Potential).  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: YME1L1
GenomeRNAi: 10730
PRO: PR:Q96TA2