GAD1 - Glutamate decarboxylase 1 - human protein (Function)
 
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Protein
Gene
References

 
GAD1 »  Glutamate decarboxylase 1   [ EC 4.1.1.15 ]
 
Protein also known as:  Glutamate decarboxylase 67 kDa isoform.
Gene name:  GAD1
Family name: Group II decarboxylase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 82 3
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the production of GABA.  
  • CuratedUniProtKB
GO molecular function 
Glutamate bindingdefinition[GO:0016595] silver  
  • IEAOrtholog Compara
Glutamate decarboxylase activitydefinition[GO:0004351]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein N-terminus bindingdefinition[GO:0047485] silver  
  • IEAOrtholog Compara
Pyridoxal phosphate bindingdefinition[GO:0030170] silver  
  • IEAOrtholog Compara
GO biological process 
Gamma-aminobutyric acid biosynthetic processdefinition[GO:0009449] silver  
  • IEAOrtholog Compara
Glutamate catabolic processdefinition[GO:0006538]  
1
  • TASUniProtKB
Glutamate decarboxylation to succinatedefinition[GO:0006540]  
1
  • TASPINC
Neurotransmitter biosynthetic processdefinition[GO:0042136]  
  • IEAUniProtKB KW
Protein-pyridoxal-5-phosphate linkagedefinition[GO:0018352]  
1
  • TASUniProtKB
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.1.15: L-glutamate 4-aminobutanoate + CO(2).  
  • CuratedUniProtKB
It requires the following cofactor
Pyridoxal phosphate.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+2571  
beta-Alanine metabolism  hsa00410+2571  
Butanoate metabolism  hsa00650+2571  
GABAergic synapse  hsa04727+2571  
Metabolic pathways  hsa01100+2571  
Taurine and hypotaurine metabolism  hsa00430+2571  
Type I diabetes mellitus  hsa04940+2571  
According to Reactome, this protein belongs to the following pathways:
GABA synthesis  REACT_24020  
GABA synthesis, release, reuptake and degradation  REACT_23947  
 
More information is available from:
 

Keywords

Biological process 
Neurotransmitter biosynthesis  definition   [KW-0530]
Molecular function 
Decarboxylase  definition   [KW-0210]
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2571
PRO: PR:Q99259