ACOX2 - Peroxisomal acyl-coenzyme A oxidase 2 - human protein (Function)
 
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Protein
Gene
References

 
ACOX2 »  Peroxisomal acyl-coenzyme A oxidase 2   [ EC 1.17.99.3 ]
 
Protein also known as:  3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase.
Gene name:  ACOX2
Family name: Acyl-CoA oxidase
Entry whose protein(s) existence is based on evidence at protein level
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1 19 1
GENE REF ISO

Function

 show evidences
Overview 
Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.  
  • CuratedUniProtKB
GO molecular function 
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activitydefinition[GO:0033791]  
  • IEAEC 2 GO
Acyl-CoA dehydrogenase activitydefinition[GO:0003995] silver  
  • IEAInterPro 2 GO
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.17.99.3: (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H(2)O + acceptor (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor.  
  • CuratedUniProtKB
It requires the following cofactor
FAD (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+8309  
Peroxisome  hsa04146+8309  
PPAR signaling pathway  hsa03320+8309  
Primary bile acid biosynthesis  hsa00120+8309  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 8309
PRO: PR:Q99424