PHOX2B - Paired mesoderm homeobox protein 2B - human protein (Function)
 
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PHOX2B »  Paired mesoderm homeobox protein 2B
 
Protein also known as:  PHOX2B homeodomain protein.
Gene name:  PHOX2B
Family name: Paired homeobox
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.  
  • CuratedUniProtKB
GO molecular function 
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDABHF-UCL
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Autonomic nervous system developmentdefinition[GO:0048483]  
1
  • IMPBHF-UCL
Brainstem developmentdefinition[GO:0003360]  
1
  • IEPBHF-UCL
Cell differentiation in hindbraindefinition[GO:0021533]  
  • ISSOrtholog Curator
Cellular response to BMP stimulusdefinition[GO:0071773]  
  • ISSOrtholog Curator
Dopaminergic neuron differentiationdefinition[GO:0071542]  
1
  • ICBHF-UCL
  • ISSOrtholog Curator
Efferent axon development in a lateral line nervedefinition[GO:0048894]  
  • ISSOrtholog Curator
Enteric nervous system developmentdefinition[GO:0048484]  
1
  • IEPBHF-UCL
Glial cell differentiationdefinition[GO:0010001]  
  • ISSOrtholog Curator
Hindbrain tangential cell migrationdefinition[GO:0021934]  
  • ISSOrtholog Curator
Inner ear developmentdefinition[GO:0048839]  
  • ISSOrtholog Curator
Medullary reticular formation developmentdefinition[GO:0021723]  
  • ISSOrtholog Curator
Negative regulation of cell cycle arrestdefinition[GO:0071157]  
  • ISSOrtholog Curator
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
  • IEAOrtholog Compara
Neural crest cell migration involved in autonomic nervous system developmentdefinition[GO:1901166]  
  • ISSOrtholog Curator
Neuron migrationdefinition[GO:0001764]  
  • ISSOrtholog Curator
Noradrenergic neuron developmentdefinition[GO:0003358]  
  • ISSOrtholog Curator
Noradrenergic neuron differentiationdefinition[GO:0003357]  
1
  • ICBHF-UCL
  • ISSOrtholog Curator
Parasympathetic nervous system developmentdefinition[GO:0048486]  
  • ISSOrtholog Curator
Positive regulation of G2/M transition of mitotic cell cycledefinition[GO:0010971]  
  • ISSOrtholog Curator
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • IMPBHF-UCL
Regulation of gene expressiondefinition[GO:0010468]  
  • ISSOrtholog Curator
Regulation of respiratory gaseous exchange by neurological system processdefinition[GO:0002087]  
  • ISSOrtholog Curator
Respiratory system developmentdefinition[GO:0060541]  
  • ISSOrtholog Curator
Retrotrapezoid nucleus neuron differentiationdefinition[GO:0061452]  
  • ISSOrtholog Curator
Skeletal muscle cell differentiationdefinition[GO:0035914] silver  
  • IEAOrtholog Compara
Sympathetic ganglion developmentdefinition[GO:0061549]  
  • ISSOrtholog Curator
Sympathetic nervous system developmentdefinition[GO:0048485]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PHOX2B
GenomeRNAi: 8929
PRO: PR:Q99453