CDC5L - Cell division cycle 5-like protein - human protein (Function)
 
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Protein
Gene
References

 
CDC5L »  Cell division cycle 5-like protein  (Cdc5-like protein)
 
Protein also known as:  Pombe cdc5-related protein.
Gene name:  CDC5L
Family name: CEF1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 78 1
GENE REF ISO

Function

 show evidences
Overview 
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).  
11
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • InterPro 2 GO
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
  • UniProtKB
WD40-repeat domain bindingdefinition[GO:0071987]  
1
  • UniProtKB
GO biological process 
DNA repairdefinition[GO:0006281]  
1
  • UniProtKB KW
mRNA splicing, via spliceosomedefinition[GO:0000398]  
1
  • UniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB KW
Signal transduction involved in DNA damage checkpointdefinition[GO:0072422]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Spliceosome  hsa03040+988  
According to Reactome, this protein belongs to the following pathway:
mRNA Splicing - Major Pathway  REACT_467  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDC5L
GenomeRNAi: 988
PRO: PR:Q99459