CD180 - CD180 antigen - human protein (Function)
 
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CD180 »  CD180 antigen
 
Protein also known as:  Radioprotective 105 kDa protein; CD antigen CD180.
Gene name:  CD180
Family name: Toll-like receptor
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).  
  • CuratedUniProtKB
GO biological process 
B cell proliferation involved in immune responsedefinition[GO:0002322] silver  
  • IEAOrtholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Positive regulation of lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031666] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD180
GenomeRNAi: 4064
PRO: PR:Q99467