PARK7 - Protein DJ-1 - human protein (Function)
 
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PARK7 »  Protein DJ-1   [ EC 3.4.-.- ]
 
Protein also known as:  Parkinson disease protein 7.
Gene name:  PARK7
Family name: Peptidase C56
Entry whose protein(s) existence is based on evidence at protein level
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1 235 1
GENE REF ISO

Function

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Overview 
Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells.  
15
  • CuratedUniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • IPIParkinsonsUK-UCL
Cupric ion bindingdefinition[GO:1903135]  
1
  • IDAParkinsonsUK-UCL
Cuprous ion bindingdefinition[GO:1903136]  
2
  • IDAParkinsonsUK-UCL
Cytokine bindingdefinition[GO:0019955]  
1
  • IPIParkinsonsUK-UCL
Not  Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • IDAParkinsonsUK-UCL
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIParkinsonsUK-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIParkinsonsUK-UCL
mRNA bindingdefinition[GO:0003729]  
1
  • IDAUniProtKB
Oxidoreductase activity, acting on peroxide as acceptordefinition[GO:0016684]  
1
  • IDAParkinsonsUK-UCL
Peptidase activitydefinition[GO:0008233]  
1
  • IDAUniProtKB
Peroxidase activitydefinition[GO:0004601] silver  
  • IEAOrtholog Compara
Peroxiredoxin activitydefinition[GO:0051920] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
8
  • IPIParkinsonsUK-UCL
  • IPIIntAct
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
3
  • IDAParkinsonsUK-UCL
  • IDAUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
Scaffold protein bindingdefinition[GO:0097110]  
1
  • IPIParkinsonsUK-UCL
Not  Single-stranded DNA bindingdefinition[GO:0003697]  
1
  • IDAParkinsonsUK-UCL
Small protein activating enzyme bindingdefinition[GO:0044388]  
1
  • IPIParkinsonsUK-UCL
Small protein conjugating enzyme bindingdefinition[GO:0044390]  
1
  • IPIParkinsonsUK-UCL
Superoxide dismutase copper chaperone activitydefinition[GO:0016532]  
1
  • IDAParkinsonsUK-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIParkinsonsUK-UCL
Ubiquitin-specific protease bindingdefinition[GO:1990381]  
1
  • IPIParkinsonsUK-UCL
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
  • IEAOrtholog Compara
Autophagydefinition[GO:0006914]  
  • IEAUniProtKB KW
Cellular response to hydrogen peroxidedefinition[GO:0070301]  
2
  • IDAParkinsonsUK-UCL
  • IDAUniProtKB
Cellular response to oxidative stressdefinition[GO:0034599]  
3
  • IDAParkinsonsUK-UCL
Dopamine uptake involved in synaptic transmissiondefinition[GO:0051583] silver  
  • IEAOrtholog Compara
Hydrogen peroxide metabolic processdefinition[GO:0042743]  
2
  • IDAParkinsonsUK-UCL
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Membrane depolarizationdefinition[GO:0051899] silver  
  • IEAOrtholog Compara
Membrane hyperpolarizationdefinition[GO:0060081] silver  
  • IEAOrtholog Compara
Mitochondrion organizationdefinition[GO:0007005]  
  • ISSOrtholog Curator
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • IDAParkinsonsUK-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaydefinition[GO:2001268]  
1
  • IMPParkinsonsUK-UCL
Negative regulation of death-inducing signaling complex assemblydefinition[GO:1903073]  
1
  • ICParkinsonsUK-UCL
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237]  
1
  • IMPUniProtKB
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • IDAParkinsonsUK-UCL
Negative regulation of hydrogen peroxide-mediated programmed cell deathdefinition[GO:1901299]  
1
  • IDAParkinsonsUK-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
2
  • IDAParkinsonsUK-UCL
  • IDABHF-UCL
Negative regulation of neuron deathdefinition[GO:1901215]  
2
  • IDAParkinsonsUK-UCL
Negative regulation of protein acetylationdefinition[GO:1901984]  
1
  • IDAParkinsonsUK-UCL
Negative regulation of protein bindingdefinition[GO:0032091]  
3
  • IMPParkinsonsUK-UCL
  • IDAUniProtKB
Negative regulation of protein export from nucleusdefinition[GO:0046826]  
1
  • IGIParkinsonsUK-UCL
Negative regulation of protein K48-linked deubiquitinationdefinition[GO:1903094]  
1
  • IDAParkinsonsUK-UCL
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • IGIParkinsonsUK-UCL
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • IGIParkinsonsUK-UCL
Negative regulation of TRAIL-activated apoptotic signaling pathwaydefinition[GO:1903122]  
1
  • IMPParkinsonsUK-UCL
Negative regulation of ubiquitin-specific protease activitydefinition[GO:2000157]  
1
  • IDAParkinsonsUK-UCL
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAGOC
  • IEAOrtholog Compara
Positive regulation of androgen receptor activitydefinition[GO:2000825]  
1
  • IMPParkinsonsUK-UCL
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
1
  • IDAParkinsonsUK-UCL
Positive regulation of oxidative phosphorylation uncoupler activitydefinition[GO:2000277] silver  
  • IEAOrtholog Compara
Positive regulation of protein homodimerization activitydefinition[GO:0090073]  
1
  • IDAParkinsonsUK-UCL
Positive regulation of protein localization to nucleusdefinition[GO:1900182]  
1
  • IDAParkinsonsUK-UCL
Positive regulation of superoxide dismutase activitydefinition[GO:1901671]  
1
  • IDAParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAParkinsonsUK-UCL
Protein stabilizationdefinition[GO:0050821]  
2
  • IDAParkinsonsUK-UCL
  • IMPUniProtKB
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of androgen receptor signaling pathwaydefinition[GO:0060765]  
1
  • IDAUniProtKB
Regulation of inflammatory responsedefinition[GO:0050727]  
  • ISSOrtholog Curator
Regulation of mitochondrial membrane potentialdefinition[GO:0051881]  
1
  • IMPParkinsonsUK-UCL
Regulation of neuron apoptotic processdefinition[GO:0043523]  
2
  • IDAUniProtKB
Not  Regulation of TRAIL receptor biosynthetic processdefinition[GO:0045560]  
1
  • IMPParkinsonsUK-UCL
Single fertilizationdefinition[GO:0007338]  
  • IEAUniProtKB KW
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Parkinson's disease  hsa05012+11315  
 

Biophysicochemical properties

Kinetic parameters
KM 173.4 uM for casein

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Fertilization  definition   [KW-0278]
Inflammatory response  definition   [KW-0395]
Stress response  definition   [KW-0346]
Molecular function 
Chaperone  definition   [KW-0143]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PARK7
GenomeRNAi: 11315
PRO: PR:Q99497