PARK7 - Protein DJ-1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PARK7 »  Protein DJ-1   [ EC 3.4.-.- ]
 
Protein also known as:  Parkinson disease protein 7.
Gene name:  PARK7
Family name: Peptidase C56
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 248 1
GENE REF ISO

Function

 show evidences
Overview 
Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells.  
16
  • UniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • ParkinsonsUK-UCL
Not  Core promoter bindingdefinition[GO:0001047]  
1
  • ParkinsonsUK-UCL
Cupric ion bindingdefinition[GO:1903135]  
1
  • ParkinsonsUK-UCL
Cuprous ion bindingdefinition[GO:1903136]  
2
  • ParkinsonsUK-UCL
Cytokine bindingdefinition[GO:0019955]  
1
  • ParkinsonsUK-UCL
Not  Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • ParkinsonsUK-UCL
Enzyme bindingdefinition[GO:0019899]  
3
  • ParkinsonsUK-UCL
Glyoxalase (glycolic acid-forming) activitydefinition[GO:1990422]  
1
  • ParkinsonsUK-UCL
Glyoxalase III activitydefinition[GO:0019172]  
1
  • ParkinsonsUK-UCL
Identical protein bindingdefinition[GO:0042802]  
2
  • IntAct
L-dopa decarboxylase activator activitydefinition[GO:0036478]  
1
  • ParkinsonsUK-UCL
mRNA bindingdefinition[GO:0003729]  
1
  • UniProtKB
Oxidoreductase activity, acting on peroxide as acceptordefinition[GO:0016684]  
1
  • ParkinsonsUK-UCL
Peptidase activitydefinition[GO:0008233]  
1
  • UniProtKB
Peroxidase activitydefinition[GO:0004601] silver  
1
  • Ortholog Compara
Peroxiredoxin activitydefinition[GO:0051920] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
12
  • IntAct
  • ParkinsonsUK-UCL
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
3
  • ParkinsonsUK-UCL
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
Repressing transcription factor bindingdefinition[GO:0070491]  
2
  • ParkinsonsUK-UCL
Scaffold protein bindingdefinition[GO:0097110]  
1
  • ParkinsonsUK-UCL
Not  Single-stranded DNA bindingdefinition[GO:0003697]  
1
  • ParkinsonsUK-UCL
Small protein activating enzyme bindingdefinition[GO:0044388]  
1
  • ParkinsonsUK-UCL
Small protein conjugating enzyme bindingdefinition[GO:0044390]  
1
  • ParkinsonsUK-UCL
Superoxide dismutase copper chaperone activitydefinition[GO:0016532]  
1
  • ParkinsonsUK-UCL
Transcription coactivator activitydefinition[GO:0003713]  
2
  • ParkinsonsUK-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • ParkinsonsUK-UCL
Tyrosine 3-monooxygenase activator activitydefinition[GO:0036470]  
1
  • ParkinsonsUK-UCL
Ubiquitin-specific protease bindingdefinition[GO:1990381]  
1
  • ParkinsonsUK-UCL
GO biological process 
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • ParkinsonsUK-UCL
Adult locomotory behaviordefinition[GO:0008344] silver  
1
  • Ortholog Compara
Autophagydefinition[GO:0006914]  
1
  • UniProtKB KW
Cellular response to glyoxaldefinition[GO:0036471]  
1
  • ParkinsonsUK-UCL
Cellular response to hydrogen peroxidedefinition[GO:0070301]  
1
  • UniProtKB
Cellular response to oxidative stressdefinition[GO:0034599]  
5
  • ParkinsonsUK-UCL
Dopamine uptake involved in synaptic transmissiondefinition[GO:0051583] silver  
1
  • Ortholog Compara
Glycolate biosynthetic processdefinition[GO:0046295]  
1
  • ParkinsonsUK-UCL
Glyoxal catabolic processdefinition[GO:1903190]  
1
  • ParkinsonsUK-UCL
Hydrogen peroxide metabolic processdefinition[GO:0042743]  
2
  • ParkinsonsUK-UCL
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB KW
Lactate biosynthetic processdefinition[GO:0019249]  
1
  • GOC
Membrane depolarizationdefinition[GO:0051899] silver  
1
  • Ortholog Compara
Membrane hyperpolarizationdefinition[GO:0060081] silver  
1
  • Ortholog Compara
Methylglyoxal catabolic process to D-lactatedefinition[GO:0019243]  
1
  • ParkinsonsUK-UCL
Mitochondrion organizationdefinition[GO:0007005]  
1
  • Ortholog Curator
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • ParkinsonsUK-UCL
Negative regulation of cell deathdefinition[GO:0060548]  
2
  • ParkinsonsUK-UCL
  • UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaydefinition[GO:2001268]  
1
  • ParkinsonsUK-UCL
Negative regulation of death-inducing signaling complex assemblydefinition[GO:1903073]  
1
  • ParkinsonsUK-UCL
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237]  
1
  • UniProtKB
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • ParkinsonsUK-UCL
Negative regulation of hydrogen peroxide-induced cell deathdefinition[GO:1903206]  
2
  • ParkinsonsUK-UCL
Negative regulation of hydrogen peroxide-induced neuron deathdefinition[GO:1903208]  
2
  • ParkinsonsUK-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • BHF-UCL
Negative regulation of neuron deathdefinition[GO:1901215]  
1
  • ParkinsonsUK-UCL
Negative regulation of oxidative stress-induced cell deathdefinition[GO:1903202]  
1
  • ParkinsonsUK-UCL
Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaydefinition[GO:1903377]  
1
  • ParkinsonsUK-UCL
Negative regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032435]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein acetylationdefinition[GO:1901984]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein bindingdefinition[GO:0032091]  
6
  • ParkinsonsUK-UCL
  • UniProtKB
Negative regulation of protein export from nucleusdefinition[GO:0046826]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein K48-linked deubiquitinationdefinition[GO:1903094]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein sumoylationdefinition[GO:0033234]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein ubiquitinationdefinition[GO:0031397]  
2
  • ParkinsonsUK-UCL
Negative regulation of TRAIL-activated apoptotic signaling pathwaydefinition[GO:1903122]  
1
  • ParkinsonsUK-UCL
Negative regulation of ubiquitin-protein transferase activitydefinition[GO:0051444]  
1
  • ParkinsonsUK-UCL
Negative regulation of ubiquitin-specific protease activitydefinition[GO:2000157]  
1
  • ParkinsonsUK-UCL
Oxidation-reduction processdefinition[GO:0055114] silver  
1
  • Ortholog Compara
Positive regulation of androgen receptor activitydefinition[GO:2000825]  
1
  • ParkinsonsUK-UCL
Positive regulation of dopamine biosynthetic processdefinition[GO:1903181]  
2
  • ParkinsonsUK-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • ParkinsonsUK-UCL
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
1
  • ParkinsonsUK-UCL
Positive regulation of L-dopa biosynthetic processdefinition[GO:1903197]  
1
  • ParkinsonsUK-UCL
Positive regulation of L-dopa decarboxylase activitydefinition[GO:1903200]  
1
  • ParkinsonsUK-UCL
Positive regulation of mitochondrial electron transport, NADH to ubiquinonedefinition[GO:1902958]  
1
  • ParkinsonsUK-UCL
Positive regulation of oxidative phosphorylation uncoupler activitydefinition[GO:2000277] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • ParkinsonsUK-UCL
Positive regulation of protein homodimerization activitydefinition[GO:0090073]  
1
  • ParkinsonsUK-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • ParkinsonsUK-UCL
Positive regulation of protein localization to nucleusdefinition[GO:1900182]  
2
  • ParkinsonsUK-UCL
Positive regulation of pyrroline-5-carboxylate reductase activitydefinition[GO:1903168]  
1
  • ParkinsonsUK-UCL
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
2
  • ParkinsonsUK-UCL
Positive regulation of superoxide dismutase activitydefinition[GO:1901671]  
1
  • ParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
6
  • ParkinsonsUK-UCL
Positive regulation of transcription regulatory region DNA bindingdefinition[GO:2000679]  
1
  • ParkinsonsUK-UCL
Positive regulation of tyrosine 3-monooxygenase activitydefinition[GO:1903178]  
1
  • ParkinsonsUK-UCL
Protein stabilizationdefinition[GO:0050821]  
3
  • ParkinsonsUK-UCL
  • UniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB KW
Ras protein signal transductiondefinition[GO:0007265]  
1
  • ParkinsonsUK-UCL
Regulation of androgen receptor signaling pathwaydefinition[GO:0060765]  
1
  • UniProtKB
Regulation of fibril organizationdefinition[GO:1902903]