PARK7 - Protein deglycase DJ-1 - human protein (Function)
 
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PARK7 »  Protein deglycase DJ-1   [ EC 3.1.2.-EC 3.5.1.- ]  (DJ-1)
 
Protein also known as:  Parkinson disease protein 7.
Gene name:  PARK7
Family name: Peptidase C56
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) (PubMed25416785). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed17015834, PubMed20304780, PubMed18711745, PubMed:12796482, PubMed19229105, PubMed25416785). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed12612053, PubMed15502874, PubMed14749723, PubMed17015834, PubMed21097510, PubMed18711745). Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed23847046). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed23792957).  
23
  • UniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • ParkinsonsUK-UCL
Copper ion bindingdefinition[GO:0005507]  
1
  • UniProtKB
Not  Core promoter bindingdefinition[GO:0001047]  
1
  • ParkinsonsUK-UCL
Cupric ion bindingdefinition[GO:1903135]  
1
  • ParkinsonsUK-UCL
Cuprous ion bindingdefinition[GO:1903136]  
2
  • ParkinsonsUK-UCL
Cytokine bindingdefinition[GO:0019955]  
1
  • ParkinsonsUK-UCL
Not  Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • ParkinsonsUK-UCL
Enzyme bindingdefinition[GO:0019899]  
3
  • ParkinsonsUK-UCL
Glyoxalase (glycolic acid-forming) activitydefinition[GO:1990422]  
1
  • ParkinsonsUK-UCL
Glyoxalase III activitydefinition[GO:0019172]  
1
  • ParkinsonsUK-UCL
Identical protein bindingdefinition[GO:0042802]  
2
  • IntAct
Kinase bindingdefinition[GO:0019900]  
1
  • UniProtKB
L-dopa decarboxylase activator activitydefinition[GO:0036478]  
1
  • ParkinsonsUK-UCL
Mercury ion bindingdefinition[GO:0045340]  
1
  • UniProtKB
mRNA bindingdefinition[GO:0003729]  
1
  • UniProtKB
Oxidoreductase activity, acting on peroxide as acceptordefinition[GO:0016684]  
1
  • ParkinsonsUK-UCL
Peptidase activitydefinition[GO:0008233]  
1
  • UniProtKB
Peroxiredoxin activitydefinition[GO:0051920] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
15
  • IntAct
  • ParkinsonsUK-UCL
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
3
  • ParkinsonsUK-UCL
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
Repressing transcription factor bindingdefinition[GO:0070491]  
2
  • ParkinsonsUK-UCL
Scaffold protein bindingdefinition[GO:0097110]  
1
  • ParkinsonsUK-UCL
Not  Single-stranded DNA bindingdefinition[GO:0003697]  
1
  • ParkinsonsUK-UCL
Small protein activating enzyme bindingdefinition[GO:0044388]  
1
  • ParkinsonsUK-UCL
Superoxide dismutase copper chaperone activitydefinition[GO:0016532]  
1
  • ParkinsonsUK-UCL
Transcription coactivator activitydefinition[GO:0003713]  
2
  • ParkinsonsUK-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • ParkinsonsUK-UCL
Tyrosine 3-monooxygenase activator activitydefinition[GO:0036470]  
1
  • ParkinsonsUK-UCL
Ubiquitin-like protein conjugating enzyme bindingdefinition[GO:0044390]  
1
  • ParkinsonsUK-UCL
Ubiquitin-specific protease bindingdefinition[GO:1990381]  
1
  • ParkinsonsUK-UCL
GO biological process 
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • ParkinsonsUK-UCL
Adult locomotory behaviordefinition[GO:0008344] silver  
1
  • Ortholog Compara
Autophagydefinition[GO:0006914]  
1
  • UniProtKB KW
Cellular response to glyoxaldefinition[GO:0036471]  
1
  • ParkinsonsUK-UCL
Cellular response to hydrogen peroxidedefinition[GO:0070301]  
1
  • UniProtKB
Cellular response to oxidative stressdefinition[GO:0034599]  
5
  • ParkinsonsUK-UCL
Detoxification of copper iondefinition[GO:0010273]  
1
  • UniProtKB
Detoxification of mercury iondefinition[GO:0050787]  
1
  • UniProtKB
Dopamine uptake involved in synaptic transmissiondefinition[GO:0051583] silver  
1
  • Ortholog Compara
Enzyme active site formation via L-cysteine sulfinic aciddefinition[GO:0018323] silver  
1
  • Ortholog Compara
Glycolate biosynthetic processdefinition[GO:0046295]  
1
  • ParkinsonsUK-UCL
Glyoxal catabolic processdefinition[GO:1903190]  
1
  • ParkinsonsUK-UCL
Hydrogen peroxide metabolic processdefinition[GO:0042743]  
2
  • ParkinsonsUK-UCL
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB KW
Lactate biosynthetic processdefinition[GO:0019249] silver  
1
  • Ortholog Compara
Membrane depolarizationdefinition[GO:0051899] silver  
1
  • Ortholog Compara
Membrane hyperpolarizationdefinition[GO:0060081] silver  
1
  • Ortholog Compara
Methylglyoxal catabolic process to D-lactatedefinition[GO:0019243]  
1
  • ParkinsonsUK-UCL
Mitochondrion organizationdefinition[GO:0007005]  
1
  • Ortholog Curator
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • ParkinsonsUK-UCL
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • ParkinsonsUK-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaydefinition[GO:2001268]  
1
  • ParkinsonsUK-UCL
Negative regulation of death-inducing signaling complex assemblydefinition[GO:1903073]  
1
  • ParkinsonsUK-UCL
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902236]  
1
  • ParkinsonsUK-UCL
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237]  
1
  • UniProtKB
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • ParkinsonsUK-UCL
Negative regulation of hydrogen peroxide-induced cell deathdefinition[GO:1903206]  
2
  • ParkinsonsUK-UCL
Negative regulation of hydrogen peroxide-induced neuron deathdefinition[GO:1903208]  
2
  • ParkinsonsUK-UCL
Negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathwaydefinition[GO:1903384]  
1
  • ParkinsonsUK-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • BHF-UCL
Negative regulation of neuron deathdefinition[GO:1901215]  
1
  • ParkinsonsUK-UCL
Negative regulation of oxidative stress-induced cell deathdefinition[GO:1903202]  
1
  • ParkinsonsUK-UCL
Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaydefinition[GO:1903377]  
1
  • ParkinsonsUK-UCL
Negative regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032435]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein acetylationdefinition[GO:1901984]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein bindingdefinition[GO:0032091]  
6
  • ParkinsonsUK-UCL
  • UniProtKB
Negative regulation of protein export from nucleusdefinition[GO:0046826]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein K48-linked deubiquitinationdefinition[GO:1903094]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein sumoylationdefinition[GO:0033234]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein ubiquitinationdefinition[GO:0031397]  
2
  • ParkinsonsUK-UCL
Negative regulation of TRAIL-activated apoptotic signaling pathwaydefinition[GO:1903122]  
1
  • ParkinsonsUK-UCL
Negative regulation of ubiquitin-protein transferase activitydefinition[GO:0051444]  
1
  • ParkinsonsUK-UCL
Negative regulation of ubiquitin-specific protease activitydefinition[GO:2000157]  
1
  • ParkinsonsUK-UCL
Positive regulation of androgen receptor activitydefinition[GO:2000825]  
1
  • ParkinsonsUK-UCL
Positive regulation of dopamine biosynthetic processdefinition[GO:1903181]  
2
  • ParkinsonsUK-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • ParkinsonsUK-UCL
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
1
  • ParkinsonsUK-UCL
Positive regulation of L-dopa biosynthetic processdefinition[GO:1903197]  
1
  • ParkinsonsUK-UCL
Positive regulation of L-dopa decarboxylase activitydefinition[GO:1903200]  
1
  • ParkinsonsUK-UCL
Positive regulation of mitochondrial electron transport, NADH to ubiquinonedefinition[GO:1902958]  
1
  • ParkinsonsUK-UCL
Positive regulation of mitochondrion degradationdefinition[GO:1903599]  
1
  • ParkinsonsUK-UCL
Positive regulation of oxidative phosphorylation uncoupler activitydefinition[GO:2000277] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • ParkinsonsUK-UCL
Positive regulation of protein homodimerization activitydefinition[GO:0090073]  
1
  • ParkinsonsUK-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • ParkinsonsUK-UCL
Positive regulation of protein localization to nucleusdefinition[GO:1900182]  
2
  • ParkinsonsUK-UCL
Positive regulation of pyrroline-5-carboxylate reductase activitydefinition[GO:1903168]