PARK7 - Protein deglycase DJ-1 - human protein (Medical)
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PARK7 »  Protein deglycase DJ-1   [ EC 3.5.1.-EC 3.1.2.- ]  (DJ-1)
Protein also known as:  Parkinson disease protein 7.
Gene name:  PARK7
Family name: Peptidase C56
Entry whose protein(s) existence is based on evidence at protein level
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1 263 1

Displayed isoform: Iso 1



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Parkinson disease 7 (PARK7) [MIM:606324]: A neurodegenerative disorder characterized by resting tremor, postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40 years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease). The disease is caused by mutations affecting the gene represented in this entry.  
  • UniProtKB
According to Orphanet, this protein is involved in the following diseases:
Amyotrophic lateral sclerosis-parkinsonism-dementia complex  90020  
Young adult-onset Parkinsonism  2828  


Disease mutation  definition   [KW-0225]
Neurodegeneration  definition   [KW-0523]
Parkinson disease  definition   [KW-0907]
Parkinsonism  definition   [KW-0908]
Tumor suppressor  definition   [KW-0043]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Organism-specific databases
CTD: 11315
GeneReviews: PARK7
MIM: 168600
MIM: 606324
PharmGKB: PA32946
Polymorphism and mutation databases
BioMuta: PARK7
DMDM: 56404943
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.