S1PR3 - Sphingosine 1-phosphate receptor 3 - human protein (Function)
 
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S1PR3 »  Sphingosine 1-phosphate receptor 3  (S1P3)
 
Protein also known as:  Endothelial differentiation G-protein coupled receptor 3.
Gene name:  S1PR3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.  
1
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
Integrin bindingdefinition[GO:0005178]  
1
  • IPIUniProtKB
Lipid bindingdefinition[GO:0008289]  
1
  • TASPINC
Sphingosine-1-phosphate receptor activitydefinition[GO:0038036] silver  
  • IEAInterPro 2 GO
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193] silver  
  • IEAOrtholog Compara
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • TASPINC
Cytokine productiondefinition[GO:0001816] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Negative regulation of establishment of endothelial barrierdefinition[GO:1903141]  
1
  • IMPUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Regulation of interleukin-1 beta productiondefinition[GO:0032651] silver  
  • IEAOrtholog Compara
Sphingosine-1-phosphate signaling pathwaydefinition[GO:0003376]  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+1903  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Lysosphingolipid and LPA receptors  REACT_18365  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: S1PR3
GenomeRNAi: 1903
PRO: PR:Q99500
Chemistry
GuidetoPHARMACOLOGY: 277