NEU1 - Sialidase-1 - human protein (Function)
 
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Protein
Gene
References

 
NEU1 »  Sialidase-1   [ EC 3.2.1.18 ]
 
Protein also known as:  N-acetyl-alpha-neuraminidase 1.
Gene name:  NEU1
Family name: Glycosyl hydrolase 33
Entry whose protein(s) existence is based on evidence at protein level
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8 50 1
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.  
1
  • CuratedUniProtKB
GO molecular function 
Exo-alpha-(2->3)-sialidase activitydefinition[GO:0052794]  
  • IEAEC 2 GO
Exo-alpha-(2->6)-sialidase activitydefinition[GO:0052795]  
  • IEAEC 2 GO
Exo-alpha-(2->8)-sialidase activitydefinition[GO:0052796]  
  • IEAEC 2 GO
Exo-alpha-sialidase activitydefinition[GO:0004308]  
1
  • IDAUniProtKB
GO biological process 
Lipid catabolic processdefinition[GO:0016042]  
  • IEAUniProtKB KW
Oligosaccharide catabolic processdefinition[GO:0009313]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.2.1.18: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.  
3
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycoside Hydrolase Family 33  GH33  
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+4758  
Other glycan degradation  hsa00511+4758  
Sphingolipid metabolism  hsa00600+4758  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Metabolism of proteins  REACT_17015  
 

Biophysicochemical properties

Dependence
pH Optimum pH is 4.6.

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Glycosidase  definition   [KW-0326]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q99519
Other
GeneWiki: NEU1
GenomeRNAi: 4758
PRO: PR:Q99519